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Malaria May Have Shaped Early Human Settlement Patterns in Sub-Saharan Africa
Science
4/23/2026AI summary

Malaria May Have Shaped Early Human Settlement Patterns in Sub-Saharan Africa

New research published in Science Advances shows that mosquito-borne malaria may have been a powerful force shaping early human settlement patterns across sub-Saharan Africa. The study found that human populations avoided malaria hotspots for at least 74,000 years, with this pattern only breaking down around 15,000 years ago when a key genetic mutation—sickle cell anemia—arose in West Africa, providing protection against the disease and allowing expansion into previously avoided areas.

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NPR News
Malaria May Have Shaped Early Human Settlement in Sub-Saharan Africa
Science
4/23/2026AI summary

Malaria May Have Shaped Early Human Settlement in Sub-Saharan Africa

Scientists at Max Planck Institute and University of Cambridge have found evidence that malaria may have been a powerful force shaping early human settlement patterns across sub-Saharan Africa. Using climate models spanning 74,000 years, researchers discovered humans avoided malaria hotspots for tens of thousands of years. Around 15,000 years ago, a key genetic mutation (sickle cell) arose in West Africa, providing protection and allowing human expansion into previously avoided regions.

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NPR News