
美國塔夫茨大學及德州大學西南醫學中心的小型研究顯示,停用GLP-1減重藥物後,使用數位健康應用程式或獲得營養師設計餐食的參與者,4個月內體重增幅僅約3.6%,低於一般照護組的10.75%,但研究規模小、追蹤時間短,尚無法確認長期效果。
AI-generated summary
GLP-1受體促效劑是一類常用於減重的藥物,但停藥後體重易回升,研究探討停藥後搭配數位健康工具或營養師餐食是否能減緩此現象。
2026/10/10 11:33
瘦瘦針注射示意圖。研究指出,停用減重藥物後搭配數位健康管理或營養師設計餐食,體重增幅較小。(資料照)
〔編譯陳成良/綜合報導〕瘦瘦針停打後,食慾可能重新增加,減掉的體重也可能逐漸回升。美國一項納入39人的小型人體試驗發現,停用減重藥物後,搭配數位健康應用程式或營養師設計的餐食,4個月內的體重增幅都低於一般照護組。不過,研究規模小、追蹤時間短,尚無法確認這些方式能否長期減緩復胖。
據《新聞週刊》(Newsweek)報導,這項研究由美國塔夫茨大學(Tufts University)及德州大學西南醫學中心(UT Southwestern Medical Center)研究人員進行,成果於10月7日刊登在《肥胖科學與實務》(Obesity Science & Practice)。研究團隊希望了解,停用類升糖素胜肽-1(GLP-1)受體促效劑後,提供有系統的飲食與生活支持,能否減少體重回升。
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試驗納入39名成年人,分成3組,分別接受一般照護、使用數位健康應用程式,或獲得營養師設計的餐食,追蹤4個月。應用程式組每天至少使用15分鐘,記錄飲食、運動及體重,並取得影響飲食行為的生理、心理、社會與環境因素相關資訊,以及管理這些因素的工具。
餐食組則獲得營養密度較高、由營養師設計的餐點,對象包括患有飲食相關疾病的參與者,例如血糖控制不佳的第2型糖尿病患者及慢性腎臟病患者。參與者每週可從70種餐點中選擇10份,再由服務單位配送到家。
數位工具與營養餐食組增重較少
4個月追蹤結果顯示,一般照護組體重增加約10.75%,使用數位健康應用程式組增加3.6%,餐食組則增加3.58%。兩個支持組的體重增幅都低於一般照護組,但並未完全避免體重增加。由於試驗只有39名參與者,這些結果仍須透過更大規模的研究確認。
研究作者之一、塔夫茨大學研究助理教授霍利斯-漢森(Kelseanna Hollis-Hansen)表示,部分患者在使用GLP-1藥物期間,可能較少接受生活習慣與行為改變方面的支持。停藥後,當飢餓感與食慾重新出現,如果缺乏管理飲食及生活習慣的策略,就可能更難維持體重。
哈佛醫學院教授、布里格姆婦女醫院體重管理與健康中心共同主任阿波維安(Caroline Apovian)指出,停用GLP-1藥物後,身體可能透過增加飢餓感、降低飽足感等生理反應,促使體重回升。她認為,飲食規劃、行為支持與運動應搭配進行,阻力訓練、增加肌肉量也可能有助體重管理。
不過,阿波維安也指出,生活介入可能只是短期解方,現階段仍缺乏能確保停藥後持續維持較低體重的荷爾蒙介入方式。研究作者表示,未來需要更長期的研究,才能確認這些支持措施的持續效果,以及停藥後需要維持多久。
AI outlook — possibilities, not facts
未來將進行更大規模、更長期的研究,以驗證數位健康應用程式和營養師餐食在停藥後體重管理中的持續效果。
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