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Back不胖不菸也心肌梗塞?醫揭健檢查不到的「隱形基因殺手」
不胖不菸也心肌梗塞?醫揭健檢查不到的「隱形基因殺手」
Health
自由时报25 minutes agoHealth5 min readChina

不胖不菸也心肌梗塞?醫揭健檢查不到的「隱形基因殺手」

國軍桃園總醫院新竹分院心血管中心主任曾國翔指出,隱形基因殺手「脂蛋白(a)」不受飲食運動影響,需透過抽血檢驗防範。

Quick Look

很多不胖、不吸菸者仍突發心肌梗塞,源於基因決定的「脂蛋白(a)」。醫師指出這項一般健檢常忽略的指標,並呼籲一生至少抽血檢查一次。

AI-generated summary

Why It Matters

根據2026年發表於《內科學誌》的最新台灣本土指引與國際研究,醫學界開始對「脂蛋白(a)」基因殺手宣戰。

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〔健康頻道/綜合報導〕很多人明明不胖、不吸菸、滴酒不沾,卻仍發生心肌梗塞!國軍桃園總醫院新竹分院心血管中心主任曾國翔表示,臨床上,他曾看過類似這樣的病友:才 40 歲出頭,不抽菸、不胖、平常抽血的「壞膽固醇 (LDL)」也完全及格,卻突然發生了嚴重的心肌梗塞。​其實,這背後往往藏著一般健檢都查不出來的「隱形基因殺手」。

曾國翔在臉書粉專「心臟Worker 曾國翔醫師」表示,根據 2026 年發表於《內科學誌》的最新台灣本土指引與國際研究,我們終於要向這個殺手宣戰了,它的名字叫做「脂蛋白(a)」(Lipoprotein(a),簡稱 Lp(a))

曾國翔表示,Lp(a) 是一種「加強版、毒性更強」的壞膽固醇。它最可怕的地方在於「完全由基因遺傳決定」,無論你怎麼運動、怎麼吃素,都無法直接降低它!

曾國翔表示,最新國際指引強烈建議,每個人「一生都應該至少抽血檢查一次 Lp(a)」! 只要提早揪出這個基因炸彈,我們就能透過 2026 最新 CKM 策略與護心八大指標,全面抵銷它的危害!曾國翔透過四大專科視角,帶您潛入基因與血管的微觀世界,看懂這場「血脂革命」:

​在生理解剖學上,我們常聽到的「壞膽固醇 (LDL)」會卡在血管壁形成斑塊。而 Lp(a) 就像是壞膽固醇穿上了一件「帶刺的毒鎧甲(載脂蛋白 a)」。這件毒鎧甲讓 Lp(a) 具備了可怕的「三重殺傷力」:

​​​●更會卡血管: 它比一般膽固醇更容易鑽進血管內皮,引發強烈的發炎反應。

​​●促進血栓形成: 它的結構長得很像人體的「溶血栓蛋白」,會去佔據位置,導致體內的血塊無法被自然溶解,極易引發心肌梗塞與中風!

​​●主動脈瓣膜鈣化: 它還會攻擊心臟的瓣膜,讓門閥提早鈣化狹窄。

​曾國翔表示,台灣約有 14% 的民眾天生就帶有高濃度的 Lp(a)。這是一個純粹的「基因樂透」!

​既然是基因決定的,那要怎麼知道自己有沒有中獎?

根據 2026 台灣血脂醫學會與國際最新共識,Lp(a) 一輩子只要抽血驗一次就夠了。如果您符合以下四大高危險特徵,曾醫師強烈建議您下次回診時加驗這項指標:

​●早發性家族史: 家裡有人在年輕時(男 < 45歲,女 < 55歲)就發生心肌梗塞或中風。

​​●莫名其妙塞血管: 年紀輕輕就中風或心梗,卻找不到傳統危險因子。

​​●反覆發作: 壞膽固醇 (LDL) 控制得很漂亮,卻還是反覆發生胸悶、支架一塞再塞!

​​●家族性高膽固醇血症 (FH) 患者。

​曾國翔表示,在台灣,只要 Lp(a) 濃度大於 30 mg/dL,心血管風險就會開始直線飆升!

​ 【曾醫師的終極拆彈手冊:發現 Lp(a) 超標怎麼辦?】

​曾國翔表示,很多人會恐慌:「曾醫師,既然吃素運動降不下來,現在的降血脂藥也對 Lp(a) 沒效,驗出來超標,怎麼辦?」曾國翔解釋,面對無法改變的基因,我們最新的戰略是「全方位撲滅其他火源」!結合 2026 CKM 治療指引 與 AHA 護心八大指標 (Life's Essential 8),打造最強防禦盾牌:

既然 Lp(a) 這個基因炸彈暫時拆不掉,根據最新「心血管-腎臟-代謝 (CKM) 症候群」指引,我們必須將其他代謝風險降到最低!對於高 Lp(a) 的病友,醫師會要求把您的「一般壞膽固醇 (LDL)」壓到極低(例如 < 55 mg/dL),並透過精準用藥將血壓、血糖、腎功能控制到完美境界,阻斷全身性發炎,就能大幅抵銷 Lp(a) 帶來的危害。

除了傳統的戒菸、規律運動、健康飲食、體重控制 (BMI),AHA 特別強調「優質睡眠」(Sleep Health)!充足的睡眠能穩定自律神經與內分泌,降低血管氧化壓力,是對抗遺傳風險的天然解藥。

醫學界沒有放棄!2026 年這篇論文特別提到,針對 Lp(a) 的「RNA 基因靜默藥物(如 Pelacarsen、Olpasiran)」已進入第三期臨床試驗。只要打一針,就能讓肝臟停止製造 Lp(a),降幅高達 80%~97%!救命神藥即將問世!

曾國翔表示,Lp(a) 檢測已納入台灣健保給付。不要讓隱藏在血液裡的基因殺手,偷走您與家人的未來!

What to Watch

AI outlook — possibilities, not facts

  • RNA基因靜默藥物將完成第三期臨床試驗。

    Likely · Within months

Open Questions

  • RNA基因靜默藥物何時能正式通過審查上市?
  • 健保未來對相關新藥的給付範圍為何?

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