
RUSH3D-HR系统首次在活体动物体内实时捕捉到针灸调控免疫器官的细胞动态
2026世界传统医药大会在北京举行,清华大学与华中科技大学团队发布AI赋能显微成像系统RUSH3D-HR。该系统首次实现活体针灸抗炎机制的可视化,通过观测小鼠脾脏中性粒细胞动态,为针灸疗效提供科学依据。
AI-generated summary
针灸作为传统医药疗法,其细胞层面的抗炎机制长期缺乏直观的实验证据。该研究通过AI与显微成像技术的结合,试图打通传统医药与现代科学的逻辑链。
中新网北京10月18日电 (记者 李纯 马帅莎)2026世界传统医药大会17日至18日在北京举办。由中国科研团队研发的新一代AI赋能活体介观三维显微成像系统RUSH3D-HR在大会期间亮相。这项研究首次在活体动物体内实时捕捉到针灸调控远端免疫器官的细胞动态变化,为传统针灸疗法提供细胞层面的“可视化证据”。
该系统由清华大学戴琼海院士团队与华中科技大学同济医学院附属同济医院王伟教授团队联合研发,相关成果已发表于国际顶级期刊《自然·生物技术》。论文共同第一作者、清华大学心理与认知科学系助理教授卢志在受访时表示,这不仅是一次技术突破,更是用现代科学语言解读传统医药的一次尝试。
据介绍,研究团队以小鼠急性炎症模型作为研究对象。实验观测到,炎症状态下,小鼠脾脏中性粒细胞数量提升约30%,且会频繁形成数百个细胞规模的“群聚”现象,事件频次约为正常小鼠的10倍。对小鼠足三里穴位施加0.5毫安电针干预后,中性粒细胞群聚事件减少5倍以上,从细胞动态层面印证了电针的抗炎调控效应。
“我们希望提供最直观的证据,把细胞变化的过程可视化,看到针灸和不针灸的情况下,细胞的运动趋势是不一样的。”卢志表示,实验同时发现,在该特定炎症模型下,不通电的传统针刺效果弱于电针,这也为不同针灸方式的效应差异提供了实验依据。
为拍下这一精微的动态过程,科研团队自主研发了“昆仑”大视场高数值孔径物镜,将成像视野拓展到毫米级,同时保持亚细胞级分辨率;再融合计算成像与人工智能算法,完成运动伪影校正、图像降噪、三维重建,数据处理速度较传统算法提升千倍以上。
卢志介绍说,“昆仑”单次实验成像通量大致相当于过去100次实验的总和,突破了活体显微成像领域长期存在的“视野与分辨率不可兼得”的瓶颈。
在本届世界传统医药大会期间,这项交叉成果为全球传统医药研究提供了全新的技术思路。在卢志看来,“传统医药现代化”的核心是打通从细胞机制到临床应用的完整逻辑链,为经过实践验证有效的疗法找到扎实的科学依据。
“除了针灸之外,还有非常多传统中医药的治疗干预方式,都可以用这种活体成像的方式,去看看能不能发现一些之前没有被观测到的现象。”卢志表示,未来团队希望把介观活体成像技术拓展到更多传统医药领域,用现代科学的方法挖掘传统医药的深层价值,为世界传统医药发展贡献中国智慧。

Wan Fengyi, a professor at Johns Hopkins Bloomberg School of Public Health, has returned to China and taken a chair professorship at Zhejiang University in Hangzhou, where he is based at a national laboratory developing intravascular devices. He is among at least five senior scientists from leading US institutions who have joined Zhejiang University full-time this year.

The 2026 Taiwan Science Circle Island Train departed from Taipei Main Station on the 19th, with the theme of "As soon as the door opens, the future unfolds", a six-day scientific journey across Taiwan was launched. 170 students from national high schools and junior colleges served as carriage gatekeepers, leading elementary school students to conduct hands-on experiments to learn about new technologies such as semiconductors, space technology, and smart medical care. Wu Chengwen, chairman of the National Science Council, said that the popular science train aims to cultivate young generations to become disseminators of popular science knowledge, stimulate curiosity and creativity, and accumulate new blood in scientific research for the country's sustainable development.

The National Extremely Weak Magnetic Technology and Application Standardization Working Group was established in Hangzhou, with Fang Jiancheng as the chairman. The working group aims to promote the standardization of scientific research results in extremely weak magnetic technology, build a standard system covering basic terminology, measurement methods and medical applications, and enhance China's international voice in this field.

During the 4th "Liangzhu Forum", the archaeological team revealed that a group of high-level buildings dating back 5,000 years were discovered on the east side of the Fanshan King's Tomb in the ancient city of Liangzhu. Through the remains of 120 pillar holes, the team restored three prehistoric buildings, speculating that they may be related to the early mausoleum system and sacrificial rituals.

The fourth annual meeting of the Intelligent Scientist Ecological Alliance was held in Hefei on the 18th, at which the Machine Scientist 2.2 system was officially released. The system integrates large models and scientific research robots, integrates a large number of scientific research facilities and models, and aims to empower the innovation of scientific research paradigms in fields such as biomedicine and new energy.

The first Dianchi International Complex Science Conference and the 70th Anniversary Frontier Physics Conference for the Discovery of the Law of Parity Nonconservation were held in Kunming from October 16 to 17, and the Kunming International Complex Science Center was simultaneously unveiled. The meeting was attended by experts and scholars from Shanghai Jiao Tong University, Tsinghua University and other universities and scientific research institutions. Wang Ning, Secretary of the Yunnan Provincial Party Committee, and Wang Yubo, Governor of Yunnan attended and delivered speeches, emphasizing promoting the integration of scientific and technological innovation and industry, cultivating new productive forces, and supporting basic research and transformation of results.