College football score predictions for Week 7, 2026: Model likes UCLA (-2.5) against Wisconsin

Indiana vs. Ohio State used to be a laugher most seasons, but times have changed in college football. It's now the biggest matchup on the Week 7 college football schedule with the fifth-ranked Buckeyes traveling to face No. 4 Indiana as 3-point road favorites after the Hoosiers beat them last season in the Big Ten title game on the way to the national title.

While that top-5 matchup is the headliner, there are also some fascinating rivalry matchups around the nation such as Tennessee (+7.5) hosting Alabama, Notre Dame (-10.5) traveling to BYU and Florida going to Texas (-11.5). The Gators could be without quarterback Aaron Philo, who is listed as questionable. Before locking in any Week 7 college football picks on those games or others, be sure to see the latest college football score predictions from SportsLine's proven model.

The model simulates every FBS game 10,000 times. It enters Week 7 on a 48-40 run on all top-rated college football picks, returning more than $400 at betting sites. Anybody following its picks on college football betting sites could have seen strong returns.

Now, it has turned its attention to the latest college football odds for Week 7 and locked in picks for every FBS matchup.

One college football score prediction for the Week 7 college football schedule at the best betting apps: The model is projecting UCLA to beat Wisconsin 23-18 in a 7:30 p.m. ET matchup at the Rose Bowl on Saturday. That makes UCLA (-2.5) the play against the spread in 57% of simulations, while the Under (43.5) hits 55% of the time.

Coming off a shocking upset of Oregon, UCLA -- now 5-0 both straight up and against the spread -- is one of the hottest programs in the nation as first-year head coach Bob Chesney has made an instant impact. A manageable schedule down the stretch has UCLA very much in the College Football Playoff conversation.

The Bruins will proceed forward without quarterback Nico Iamaleava (knee), but the Bruins were mostly getting it done with the Big Ten's top rushing offense and a solid defense, so the model isn't projecting a huge drop off with Ty Dieffenbach under center.

The model has revealed an exact score prediction for each Week 7 college football game. It is backing multiple underdogs to win outright, including a big upset in one of the week's biggest games.