Eagles vs. Jaguars prediction, odds, time: 2026 Week 5 NFL London Game picks from proven model

A cross-conference matchup in Week 5 will head overseas as the Jacksonville Jaguars meet the Philadelphia Eagles in an NFL London Game. The Jags (3-1) are the designated home team and coming off back-to-back wins, defeating Cincinnati, 22-17, in Week 4. The Eagles (2-2) have dropped two in a row and are dealing with an assortment of absences. Saquon Barkley (hamstring) and DeVonta Smith (hamstring) are among those out, while longtime OT Lane Johnson abruptly retired mid-week.

Kickoff is set for 9:30 a.m. ET from Tottenham Hotspur Stadium in London, England. The Jags are 7-7 all-time in international games, while Philadelphia is 2-0. The latest Jaguars vs. Eagles odds have Jacksonville as a 7.5-point favorite, while the over/under is 41.5. Jacksonville is at -395 on the money line. Before making any Eagles vs. Jaguars picks, be sure to see the 2026 NFL London Game predictions from SportsLine projection model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 5 of the 2026 NFL season on a 55-44 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns.

Now, the model has zoned in on Jaguars vs. Eagles. You can head to SportsLine now to see its picks. Here are several NFL odds and betting lines for Eagles vs. Jaguars:

Top Eagles vs. Jaguars predictions

After 10,000 simulations of Jags vs. Eagles, the model is going Under 41.5 points at betting apps. Each of the Jags' last three games have gone under as their defense is elite in all regards. They've allowed the fewest passing touchdowns, have the second-best scoring defense and rank third in defending the run. Also, no team is as familiar with international games away from home quite like the Jags, as the Under sports a 7-2 record over their last nine neutral-site contests.

The Eagles should also contribute to the Under hitting, considering their heavily depleted offense. In addition to Barkley and Smith out, the team will also be without Barkley's backup in Tank Bigsby plus wideout Hollywood Brown, as it could be a struggle to put points on the board. Add in that the Eagles have seen the Under go 5-1 over their last six games versus AFC opponents, and the model projects the Under to hit in 58% of simulations. See which team to back at SportsLine.

How to make Jaguars vs. Eagles picks

In addition to going Under, the model also says one side of the spread has all of the value. See what it is at SportsLine.