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Back研究發現替爾泊肽可能啟動棕色脂肪 而非僅降低食慾
研究發現替爾泊肽可能啟動棕色脂肪 而非僅降低食慾
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自由时报1 hour agoHealth2 min readChinaView translation

研究發現替爾泊肽可能啟動棕色脂肪 而非僅降低食慾

替爾泊肽棕色脂肪減重藥物

Quick Look

西班牙巴塞隆納大學研究團隊發現，減重藥物替爾泊肽除了降低食慾外，可能直接啟動小鼠體內的棕色脂肪，增加能量消耗。研究透過控制食物攝取量排除少吃因素，結果顯示棕色脂肪出現明顯活化。研究團隊強調結果來自小鼠實驗，人體效應仍需更多臨床驗證。

AI-generated summary

Why It Matters

替爾泊肽是同時作用於GIP與GLP-1兩種荷爾蒙受體的藥物，目前用於猛健樂（Mounjaro）及Zepbound等減重藥物，過去已知的減重效果主要與降低食物攝取有關。

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2026/10/05 11:47

最新小鼠研究發現，一種常見減重藥物成分可能能啟動體內負責消耗能量的「棕色脂肪」。示意圖，圖中人物與新聞無關。（圖取自shutterstock）

〔編譯陳成良／綜合報導〕「瘦瘦針」幫助減重，常被認為主要是透過降低食慾、減少進食量，但最新小鼠研究發現，其中一種常見減重藥物成分可能還有另一條作用途徑，能啟動體內負責消耗能量的「棕色脂肪」，讓科學家對這類藥物如何影響代謝有更多線索。

據科學網站《Science Daily》報導，西班牙巴塞隆納大學（University of Barcelona）研究團隊以肥胖小鼠進行實驗，研究對象是替爾泊肽（tirzepatide），這項成分目前用於猛健樂（Mounjaro）及 Zepbound 等藥物。研究發現，替爾泊肽除了減少食物攝取，也可能直接影響脂肪組織，其中棕色脂肪出現明顯活化現象。

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排除少吃因素 小鼠照樣燃燒熱量

研究團隊特別設計實驗，讓未接受藥物的小鼠攝取與用藥小鼠相同分量的食物，再比較兩組動物的脂肪組織變化。這項安排是為了排除「單純因為吃得比較少」造成的影響，進一步觀察替爾泊肽本身是否會改變身體的能量代謝。結果顯示，接受替爾泊肽的小鼠，其體內的棕色脂肪確實出現活化。

棕色脂肪與一般主要負責儲存能量的白色脂肪不同，主要功能之一是消耗能量並產熱，因此被視為調節能量消耗的重要組織。研究人員指出，棕色脂肪活化後，與代謝能量消耗增加及相關分子產生有關，這也讓替爾泊肽的作用機制可能不只停留在降低食慾。

替爾泊肽本身是同時作用於GIP與GLP-1兩種荷爾蒙受體的藥物，過去已知的減重效果主要與降低食物攝取有關。這項研究則提供另一個可能方向，也就是藥物除了影響「吃進多少」，可能還會改變身體「消耗多少」能量。

研究成果已刊登於《生物醫學與藥物治療》（Biomedicine & Pharmacotherapy）期刊。研究團隊強調，目前結果來自小鼠實驗，不能直接推論在人體也會產生相同效果，人類與小鼠在代謝調節、脂肪分布及藥物反應上存在差異，未來是否能在人體確認替爾泊肽對棕色脂肪的實際作用，仍需更多臨床研究驗證。

What to Watch

AI outlook — possibilities, not facts

  • 未來將進行人體臨床試驗以驗證替爾泊肽對棕色脂肪的影響

    Likely · Within months

Open Questions

  • 替爾泊肽在人體中是否真的能啟動棕色脂肪？
  • 棕色脂肪的活化程度在人體中會帶來多少額外的能量消耗？
  • 這種作用是否會導致副作用或長期安全問題？
  • 是否有其他減重藥物也具備類似的棕色脂肪啟動效應？

Related Topics

替爾泊肽
People陳成良
Organizations巴塞隆納大學Science DailyBiomedicine & Pharmacotherapy
Places巴塞隆納西班牙
Topics棕色脂肪減重藥物巴塞隆納大學小鼠實驗能量代謝tirzepatide
This article was originally published by 自由时报.

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