Taking GLP-1 drugs has been linked to nail and hair problems

Taking GLP-1 drugs, which are used to treat obesity and type 2 diabetes, has been associated with an increased incidence of nail problems, including peeling nails. This was shown by the first study of such an effect, presented at the 2026 Congress of the European Academy of Dermatology and Venereology (EADV).

The researchers compared 575 people taking GLP-1 receptor agonists with 1,329 obese or diabetic patients who had never used such drugs. Detachment of nails was observed in 39 percent of participants in the first group versus 9 percent in the second—that is, more than four times more often.

Overall, 66 percent of those taking GLP-1 experienced at least one nail problem versus 53 percent of the control group. Changes in nail color were also noticeably more common—46 percent versus 17 percent.

The difference could not be entirely explained by weight loss. Even after accounting for weight loss, skin conditions, and nutritional deficiencies, nail peeling and discoloration remained about two to three times more common among those taking the drugs.

In a separate analysis, scientists also found more frequent hair and scalp problems. Unusual hair loss was reported by 50 percent of those taking GLP-1 versus 34 percent of the control group, and loss of hair volume was reported by 42 percent versus 19 percent.

The authors emphasize that you should not stop treatment on your own if such symptoms appear—they should be discussed with your doctor.