
The Michigan Wolverines host the No. 6 Indiana Hoosiers at The Big House in a Week 8 conference matchup.
AI-generated summary
Michigan leads the all-time series 62-11. Indiana won the most recent meeting in 2024.
The Michigan Wolverines will host the No. 6 Indiana Hoosiers for a Big Ten clash on Saturday that kicks off at noon ET in "The Big House." Michigan is 4-2 on the season and 1-2 in conference play coming off a 21-18 win over Penn State last week, while Indiana is 6-1 overall and 3-1 in the league after a 19-15 loss to Ohio State at home. The Wolverines own a 62-11 advantage in the all-time series, but Indiana scored a 20-15 win when the programs last met in 2024.
We'll look at the latest Michigan vs. Indiana odds and the Indiana vs. Michigan spread at DraftKings Sportsbook before breaking down this Big Ten matchup. We'll also share our best bets from the SportsLine Projection Model. Anybody following SportsLine's picks on college football betting sites could have seen strong returns.
Michigan vs. Indiana betting odds (via DraftKings)
Michigan vs. Indiana money line: Michigan +240, Indiana -298 Michigan vs. Indiana over/under: 42.5 (Over -110, Under -110) Michigan vs. Indiana spread: Indiana -7.5
Michigan vs. Indiana betting preview
These two programs first met in 1900 and it's been mostly Wolverines since. The Hoosiers have only won back-to-back games in the series twice over a span of 73 meetings, but they'll have the chance to do if for a third time after winning in Bloomington during Curt Cignetti's first season in 2024. This will be Kyle Whittingham's first head-to-head matchup with Cignetti.
The former Utah head coach who is now in his first year at Michigan is playing his cards close to his vest about who will start at quarterback. Tommy Carr and Bryce Underwood split reps last week against Penn State. Cignetti indicated that he assumed it'd be Carr under center in Week 8, but that Indiana is preparing for both quarterbacks.
However, it was the Michigan rushing attack that led the charge against the Nittany Lions, as the Wolverines rushed for 211 yards and three scores. Meanwhile, the Hoosiers have only rushed for 138 yards on 51 carries over the last two weeks against Ohio State and Nebraska. So whoever wins in the trenches might have the advantage in Ann Arbor.
Indiana vs. Michigan pick, prediction
Indiana -7.5 vs. Michigan (-111)
AI outlook — possibilities, not facts
Indiana covers the -7.5 spread
Possible · Within days

Milwaukee Brewers catcher William Contreras delivered a standout performance in Game 1 of the 2026 World Series, driving in a run and shutting down Tampa Bay's base-stealing threats to secure a 3-2 victory.

Week 7 of the NFL season features key divisional matchups and interconference games. SportsLine AI provides betting predictions, including a projected 25-18 Broncos victory over the Cardinals, while Philadelphia moves forward without Jalen Hurts.

Expert betting analysis for NFL Week 7, featuring spread picks for Vikings, Lions, and Dolphins games, along with player props for Ja'Marr Chase and Jaylen Warren, and anytime touchdown scorer recommendations.

UFC 333 takes place Saturday at Etihad Arena in Abu Dhabi, featuring featherweight champion Alexander Volkanovski against Movsar Evloev and a bantamweight trilogy bout between Petr Yan and Merab Dvalishvili.

The Week 7 NFL schedule features unique matchups like the first-ever game in Paris. SportsLine's computer model, which has a strong historical track record, provides betting predictions and spread analysis for all upcoming games, including Jets vs. Dolphins.

Former NBA player Malik Beasley is in negotiations for a plea deal regarding his alleged role in a sports gambling scheme. Beasley was indicted for manipulating his own game statistics to help co-conspirators win prop bets to cover gambling debts.