
SportsLine NFL expert Mike Tierney shares his best Week 10 parlay bets, including favorites and underdogs across multiple matchups.
SportsLine NFL expert Mike Tierney reveals his Week 10 parlay picks, featuring favorites (Rams, Seahawks, Chiefs) and underdogs (Panthers, Steelers, Chargers) with analysis of rookie quarterbacks, injuries, and key matchups.
AI-generated summary
SportsLine NFL expert Mike Tierney, a veteran sportswriter whose work appears in the New York Times and Los Angeles Times, has covered the NFL for decades and reported from seven Super Bowls. He is 320-271-16 in the NFL over the past four seasons, returning $1,867 to $100 players, including 130-101 ATS (56.3 percent) over the past two seasons.
Football fans looking to get into NFL betting, specifically parlay betting, have plenty of options when looking at the Week 10 slate. SportsLine NFL expert Mike Tierney has highlighted some of his best bets when putting together two parlays, one for favorites and one for underdogs, including a pair of rookie quarterbacks in tough spots and a future Hall of Famer delivering in primetime.
Tierney is a veteran sportswriter whose work appears periodically in the New York Times and Los Angeles Times, and he has covered the NFL for decades and reported from seven Super Bowls. He is 320-271-16 in the NFL the past four seasons, returning $1,867 to $100 players. That includes Mike going 130-101 ATS (56.3 percent) the past two seasons. Here are his best parlays for Week 10.
NFL Week 10 favorites parlay
Rams money line vs. Cardinals
We could just package the trio of hefty faves and cash on the near-locks, but what fun would that be? Instead of Jaguars over Titans and Bills over Jets, let's zero in on the Rams, a virtual cinch even with WR Puka Nacua, who seemed to be Matthew Stafford's lone target, shelved with an injury. The all-world defensive tag team of Myles Garrett and Aaron Donald against rookie QB Carson Beck? Cruel and unusual punishment. Minus Jeremiyah Love and Michael Wilson, 'Zona's best RB and WR, Beck's offense is left bare. Seriously, it might be even money that the Cardinals find the end zone.
Seahawks money line vs. Raiders
Here's another play-against involving a rookie quarterback. Fernando Mendoza is a cut above Beck, but he was dealt a bad hand for his inaugural start. Mendoza, who mopped up with eight passes in one blowout loss, would have picked another defense — in fact, any other defense — than Seattle's. It's the stingiest overall and against the pass. Drew Lock, on duty for the rehabbing Sam Darnold, has served as more of a game manager but is unbeaten as a 'Hawks starter. The Raiders' defense is the polar opposite — worst in the league overall against the run. Lock is likely not going to need to air it out to hand-deliver a win.
Chiefs money line vs. Falcons
This says it all about KC-Atlanta: the Chiefs acquired WR Josh Downs via trade, while the Falcons dealt S Jessie Bates II and C Ryan Neuzil. Though Patrick Mahomes is nursing a sore elbow, as long as he has RB Kenneth Walker III alongside him, the Chiefs are good to go. Downs provides Mahomes with an extra target. The Falcons have fallen in four of the last five, which persuaded management to ostensibly punt on the season. Home-field advantage has diminished this year, and Atlanta's 1-4 record is a prime example.
NFL Week 10 underdogs parlay
Panthers money line vs. Saints
When evaluating a coin flip game, we tend to lean toward the team that has shown more upside. The Panthers' three wins came by a combined 48 points, the Saints' three by 15, with one occurring in overtime. Carolina is the NFL's most pass-happy team, while New Orleans yields the 29th most yards and 28th most catches per game. Injuries have been a Panthers bugaboo. A half-dozen players resumed practice this week, though their status remains iffy. The Saints stand 1-4 in their friendly confines.
Steelers money line vs. Bengals
Can Pittsburgh really sweep the season series with Cincinnati? The Bengals are back from a game in Madrid, while the Steelers lounged last weekend with a bye. There are five instances when a team that had been idle faced an opponent coming off an international gig, and the refreshed side won 'em all. Cincy's offense is aflame, with 30-plus points registered in four straight outings. The Steelers counter with the fourth-most unforgiving defense, allowing 18 points per game.
Chargers money line vs. Ravens

Tarik Skubal, the two-time AL Cy Young winner and top free agent, is expected to sign a record contract worth potentially over $400 million before the collective bargaining agreement expires at 11:59 p.m. ET on Dec. 1, which could trigger an owners' lockout. Several big-market clubs including the Blue Jays, Dodgers, and Mets are pursuing him, while a short-term, high-annual-salary alternative remains possible.

Week 10 NFL features divisional matchups including Bills vs. Jets, Panthers vs. Saints, Jaguars vs. Titans, Vikings vs. Packers, Rams vs. Cardinals, and Steelers vs. Bengals on Sunday Night Football, plus Texans vs. Browns, Dolphins vs. Colts, and 49ers vs. Cowboys. SportsLine AI projects a 38-28 Bills win over the Jets and likes Buffalo at -7.5 ATS and Over 50.5.

The Week 10 NFL DFS main slate features 10 games headlined by Cowboys vs. 49ers with a 55.5 over/under. SportsLine expert Mike McClure highlights Dolphins running back Ollie Gordon II and Cowboys receiver CeeDee Lamb as top picks for Sunday.

Week 10 NFL schedule features 13 remaining games including Vikings vs. Packers, Cowboys vs. 49ers, and Bengals vs. Steelers. Rookie quarterback Fernando Mendoza makes his first NFL start as the Raiders host the Seahawks as 6.5-point underdogs. Betting odds are provided for every matchup.

The Jacksonville Jaguars acquired safety Jessie Bates III and defensive tackle Jordan Davis at the trade deadline, but both will miss the Week 10 road game against division rival Tennessee because neither has had a bye week yet. Defensive tackle Davon Godchaux, acquired from New Orleans, will play Sunday.

USMNT head coach Mauricio Pochettino will leave the American national team after the two Nations League matches against Haiti to become Manchester United's new manager, following the sacking of Michael Carrick. The article also lists potential USMNT successors including Steve Cherundolo, Pep Guardiola, and Roberto Martinez.