Ohio State vs. Indiana prediction, odds, time: Week 7 college football picks by proven model

No. 4 Ohio State travels to Bloomington for one of the most compelling Big Ten matchups of the 2026 season, visiting defending national champion Indiana. The Buckeyes (5-1) arrive with quarterback Julian Sayin and receiver Jeremiah Smith, both Heisman contenders, looking for a statement win against a top-10 team.

No. 5 Indiana (6-0) turned to TCU transfer quarterback Josh Hoover, who has kept the Hoosiers undefeated this season despite some close calls. The Hoosiers beat Ohio State 13-10 in the Big Ten title game last year for their first win in the series since 1988.

Kickoff is set for noon ET at Memorial Stadium in Bloomington, Ind. The Buckeyes are 3-point road favorites in the latest Ohio State vs. Indiana odds, with the over/under at 50.5 points. Before making any Indiana vs. Ohio State picks, check out the Ohio State vs. Indiana predictions from the SportsLine Projection Model.

After simulating Ohio State vs. Indiana 10,000 times, SportsLine model is going Over 50.5 points at betting apps. Ohio State's offense has been dynamic with Sayin under center, and despite Indiana playing a more conservative home style under Hoover, the model projects both units to generate enough production to push the combined score past the current total. The Buckeyes bring a high-powered attack into Memorial Stadium that has shown the ability to put up points in conference play, while Indiana's offense has stayed efficient through three games and should keep pace in what figures to be a competitive Big Ten contest.

Ohio State's last game went Over the total, and three of their last four games have gone Over the total. Two of Indiana's last three games have gone Over the total.

SportsLine's model is projecting 51 combined points in this one, making the Over the value 51% of the time. See the model's spread and money-line picks at SportsLine.

In addition to going Over on the total, the model also says one side of the spread hits in 60% of simulations. You can only get the pick at SportsLine.