Panthers vs. Eagles odds, picks, prediction, spread: Start time, betting preview, best bets for NFL Week 6
Philadelphia hosts Carolina with Tanner McKee starting at quarterback for the injured Jalen Hurts.
Quick Look
- The Philadelphia Eagles host the Carolina Panthers in Week 6 without starting quarterback Jalen Hurts, who is out with a blood clot issue.
- Carolina enters as 3.5-point favorites with a 2-2 record, while Philadelphia sits at 2-3.
AI-generated summary
Why It Matters
The Philadelphia Eagles and Carolina Panthers face off in Week 6 of the NFL season. Philadelphia is coming off a 19-17 loss in London.
Two division winners from a year ago clash as part of the NFL's Week 6 schedule with the Philadelphia Eagles hosting the Carolina Panthers.
These teams enter this contest in very different fashion, as Carolina is coming off a bye after taking down Detroit on Sunday Night Football in Week 4, while a late special teams gaffe cost the Eagles over in London as they fell 19-17 on a last-second field goal.
The Panthers are 2-2 and the Eagles are 2-3, and Philadelphia will be without starting quarterback Jalen Hurts due to a blood clot issue. Kickoff for this matchup is set for 1 p.m. ET. The Panthers are 3.5-point favorites at DraftKings Sportsbook, and the Over/Under is 38.5.
We'll break down the latest Panthers vs. Eagles odds from DraftKings and deliver our best bets for the contest with help from the SportsLine Projection Model. The model, which simulates every NFL game 10,000 times, is up more than $5,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 6 of the 2026 NFL season on a 57-46 run on top-rated picks dating back to 2024.
The Eagles' offense has been a mess this year, and things will only be more difficult against the Panthers on Sunday with Hurts out. The veteran quarterback was a full participant on Wednesday but had a calf injury designation. But news broke Thursday that he'd be out for Sunday, pushing Tanner McKee into action.
The Eagles are 58-25 when Hurts starts since 2021 and average 25.4 points per game. While Philly is 3-4 in games started by other quarterbacks, the team is averaging 25.9 points per game and a few more yards per contest in his absence. The Eagles get one of their best weapons back this week in DeVonta Smith, who is off the injury report, but star running back Saquon Barkley is out once again.
On the other side, the Panthers' offense has been a bright spot in the early going. Between Bryce Young's hot play and Chuba Hubbard carrying the load at running back, Carolina is fourth at 30.3 points per game. The defense is another story, though, sitting 26th at 27.3 points allowed per game.
The Panthers are 2-2 against the spread this year, and the Eagles are just 1-4 ATS. Philly is 3-2 to the Over this year and Carolina is 2-2.
Open Questions
- How will Tanner McKee perform in place of Jalen Hurts?
- Can the Panthers' defense contain the Eagles' depleted offense?
