Rams and 49ers Meet in First-Ever NFL Australia Game in Melbourne

The Rams and 49ers meet in the first-ever NFL Australia Game on Thursday night in Melbourne, as the NFC West rivals square off after splitting their season series last year. Los Angeles is a 3.5-point favorite, according to the latest NFL betting odds, with the over/under at 48.5.

Kickoff for Rams vs. 49ers is set for 8:35 p.m. ET at Melbourne Cricket Ground in Melbourne, Australia. SportsLine's team of NFL experts have analyzed 49ers vs. Rams and revealed their two best bets, and you can also read our NFL betting preview for the NFL Australia Game.

Rams vs. 49ers betting preview

Los Angeles and San Francisco will play the first-ever NFL game in Australia on Thursday, with the NFC West rivals hoping to get off to a strong start. They split their season series last year, as the road team won both matchups. Rams quarterback Matthew Stafford, who ultimately won the NFL MVP, had seven touchdowns and zero interceptions across those two games.

The 49ers were without quarterback Brock Purdy and defensive end Nick Bosa in both of those games. They are trying to win their third consecutive season opener after taking down the Seahawks in Week 1 last year. The Rams are 3.5-point favorites in the Rams vs. 49ers odds, while the over/under is 48.5.

Rams vs. 49ers picks, best bets

Christian McCaffrey Under 60.5 rushing yards (-114)

Deebo Samuel Over 2.5 receptions (-142)

Christian McCaffrey Under 60.5 rushing yards (-114)

"I was a big Christian McCaffrey supporter heading into 2025 and believed he would stay healthy and excel," SportsLine expert Eric Cohen said. "I'm on the other side of the fence this season. After 450 touches last year, I expect the 30 year old RB to wear down and potentially see reduced workloads early in the season. Last year against the Rams, CMC combined for only 87 yards rushing and did a lot more damage in the passing game. With Los Angeles' defensive line MUCH stronger this year, the 49ers would be smart to throw their running back the ball instead of run him into the line. Either way, I think LA holds McCaffrey to under 50 rushing yards in Australia."

Deebo Samuel Over 2.5 receptions (-142)