Saints vs. Giants odds, picks, prediction, spread: Start time, betting preview, NFL Week 6 best bets

The New Orleans Saints will face the New York Giants in Week 6 of the 2026 NFL season on Sunday. The Giants are off to a strong start despite a season-ending injury to quarterback Jaxson Dart but come in off a tie with the Commanders. New York had a chance at the victory in overtime but missed a field goal on its opening possession and then fumbled on a subsequent drive. Kickoff is set for 1 p.m. ET at MetLife Stadium. Despite their recent struggles, the visitors are 1.5-point favorites in the Saints vs. Giants odds, and the Over/Under is 46.5.

We'll take a look at the latest Saints vs. Giants odds at DraftKings and provide our best bet for the contest with help from the SportsLine Projection Model. The model, which simulates every NFL game 10,000 times, is up more than $5,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 6 of the 2026 NFL season on a 57-46 run on top-rated picks dating back to 2024.

Saints vs. Giants betting odds (via DraftKings)

Saints vs. Giants money line: Saints -112, Giants -108 Saints vs. Giants Over/Under: 45.5 (Over -105, Under -115) Saints vs. Giants spread: Saints -1.5

Saints vs. Giants betting preview

New Orleans came into the 2026 season as a sleeper team after a strong finish to 2025. The Saints have not been fortunate on the injury front, with big free agent signing Travis Etienne still on IR and first-round pick Jordyn Tyson sidelined. Tyler Shough has amassed gaudy numbers, but that's largely because the team has been playing from behind. The Saints have not been great defensively, though they did hold their own last week against the Vikings. Shough was particularly poor against Minnesota's defense, throwing for less than 100 yards while also tossing two picks. He'll try to get back in form against a Giants defense that is allowing 21.2 points per game.

Jameis Winston has taken over for Dart, and while he's had some reckless moments, the offense has been humming along. New York is averaging 21.8 points per game as Cam Skattebo, Malik Nabers and Isaiah Likely all chip in. Last week's tie has taken a lot of momentum away from the Giants, but they are still in first place in the NFC East entering Week 6. If Winston can play turnover-free football, New York should be able to move the ball against this New Orleans defense. Winston didn't throw an interception last week against the Commanders while tossing three touchdown passes.