Grape polyphenols may protect the brain against age-related changes
Quick Look
Scientists at the University of East Anglia have concluded that polyphenols contained in grapes have the potential to protect the brain against age-related changes and support cognitive function by reducing inflammation and oxidative stress, which was confirmed in clinical trials in older people.
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Why It Matters
Polyphenols are plant compounds that have antioxidant properties. Grapes are one of the rich sources of polyphenols such as resveratrol and flavonoids.
Polyphenols contained in grapes have the potential to protect the brain from age-related changes and support cognitive function. This is the conclusion reached by scientists at the University of East Anglia. Their review was published in the journal Nutrients.
The authors examined research on the effects of grapes and the polyphenols they contain on brain function. These substances can reduce inflammation and oxidative stress, and support the function of blood vessels and nerve cells.
In one study, 143 people aged 60 to 80 with mild cognitive impairment took grape and blueberry extract for six months. Compared to placebo, they showed greater improvements in processing speed and learning ability.
In another trial, 96 older adults took grape extract for 12 weeks. Their memory, attention, speech and visuospatial abilities improved, with some changes appearing after just two weeks.
Scientists attribute the possible effect of polyphenols to their influence on inflammation, blood supply and nerve cell function. However, the data obtained relate to grape polyphenols and do not prove the benefits of drinking wine.
Open Questions
- What is the optimal dose of grape polyphenols for cognitive protection?
- Are there long-term effects of taking grape extract?
- What specific mechanisms of action of polyphenols on nerve cells are most significant?
