Scientists have found a way to speed up the healing of infected wounds

Scientists from Sechenov University, together with Russian and Chinese colleagues, have found a way to speed up the healing of infected wounds. In experiments on mice, advanced photodynamic therapy reduced inflammation and helped the skin recover faster. The university press service reported this to Lenta.ru.

With photodynamic therapy, a special light-sensitive substance is applied to the wound, after which it is exposed to light of a certain wavelength. As a result, reactive oxygen species are formed, which damage bacteria.

To increase the effectiveness of the therapy, the scientists used two light-sensitive substances - methylene blue and a chlorine derivative e6 - and supplemented them with polymer components Pluronic F108 and sodium alginate. Pluronic F108 helps light-sensitive molecules remain active and act more effectively after irradiation. Sodium alginate creates an environment favorable for the restoration of damaged tissue.

The method was tested on mice with skin wounds infected with Staphylococcus aureus. The animals underwent two therapy sessions, after which the healing process was monitored for 13 days. When using the most effective formulations, the wounds were practically closed by the ninth day. Combinations based on methylene blue showed especially good results.

Scientists also studied the condition of the restored skin. The treatment reduced inflammation and promoted the formation of mature connective tissue and properly aligned collagen fibers. In addition, new hair follicles appeared in the skin. Thus, the method not only accelerated the closure of the wound, but also helped restore the normal structure of the skin.