Broncos vs. Seahawks odds, prediction, betting preview, start time: Thursday Night Football picks, best bets

The Seattle Seahawks and Denver Broncos meet in a rematch of the 2014 Super Bowl when they square off on Thursday Night Football to kick off NFL Week 6. Both teams are 3-2 through the first five weeks of the season, but Seattle is coming off a loss to San Francisco while Denver beat the Chargers. The Seahawks are 2.5-point road favorites in the Broncos vs. Seahawks odds, and the over/under is 40.5.

Kickoff for Broncos vs. Seahawks is set for 8:15 p.m. ET at Empower Field at Mile High in Denver, Colorado. SportsLine's team of NFL experts have analyzed TNF and revealed their Seahawks vs. Broncos prediction, and you can also read our NFL betting preview for Thursday Night Football.

There are many parallels between these teams, as both are 3-2 and coming off 14-3 campaigns in 2025. They also both finished 10-7 in 2023. Seattle is trying to avoid being the first defending champion to go 3-3 or worse to start the following season since the Rams in 2022, and it has won five straight games following a loss.

The Seahawks lost to San Francisco by three points last week, as wide receiver Cooper Kupp was stopped short on fourth down at the 49ers' 41-yard line with 47 seconds remaining. Denver is coming off a 23-17 win over the Chargers, erasing a 17-10 deficit. The Broncos are the first team to start 3-2 or better despite trailing by at least seven points in the second half in all five games since the 1981 Bengals, who reached the Super Bowl.

"It appears the Broncos will be without top corner Patrick Surtain and their best defensive playmaker in Talanoa Hufanga, both due to ankle injuries," SportsLine expert Larry Hartstein said. "Denver has not played without Hufanga yet -- he is a difference-maker with 23 tackles, two INTs (including a Pick-6), a sack, and forced fumble. Denver's other starting corner, Riley Moss, is dealing with a rib injury and is iffy. While the Seahawks have been plagued by turnovers, they've been much better on a per-play basis. Seattle has outgained its opponents by 1.4 yards per play while Denver has been outgained by 0.5 yards per play. Since Mike Macdonald took over, the Seahawks are 16-3 SU and 13-5-1 ATS on the road."