Colts vs. Steelers odds, picks, prediction, spread, line: Start time, preview, best bets for NFL Week 5

It's a matchup of 2-2 teams in Pittsburgh on Sunday as the Indianapolis Colts visit the Steelers in Week 5 of the NFL season. Pittsburgh is third in the AFC North, while the Colts are in second place in the AFC South. DraftKings Sportsbook lists the Steelers as 3-point favorites and has the Over/Under for total points set at 43.5. Kickoff at Acrisure Stadium is set for 1 p.m. ET. Spend $5+ on Colts-Steelers in Week 5 with the latest DraftKings promo code and get $150 in bonus bets:

We'll break down the latest Colts vs. Steelers odds from DraftKings Sportsbook and deliver our best bets for the contest with help from the SportsLine Projection Model. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 5 of the 2026 NFL season on a 55-44 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns.

Colts vs. Steelers betting odds (via DraftKings)

Colts vs. Steelers money line:Colts +130, Steelers -155Colts vs. Steelers over/under:43.5 (Over -108, Under -112)Colts vs. Steelers spread: Steelers -3

Colts vs. Steelers betting preview

This battle of Midwest middleweights poses an interesting question -- would you rather have a game-warping offensive star or a decent defense?

Option No. 1 gives you the Colts, who need running back Jonathan Taylor to lead the way with top wideout Alec Pierce on the shelf. Taylor entered Week 5 fifth in rushing yards and with six scores on the ground. He's still the bread and butter of the Indy offense, ensuring Daniel Jones isn't wholly relied upon to win games with his arm.

Option No. 2 gives you the Steelers, who have been roughly average in yards allowed per game -- a claim that can't be made by the Colts, who have given up an unsightly 392.3 yards per game, the second most in the league. While Pittsburgh doesn't have a superstar playmaker on offense, the Steelers can get stops and move the ball. Aaron Rodgers is far from an MVP candidate these days, but he can still throw the ball a bit.

While this shouldn't exactly be a shootout, depending on your definition of the term, it could still turn into a game where the last team to score wins. Wager on NFL Week 5 games, including Colts-Steelers, with the latest BetMGM bonus code CBSSPORTS to get up to $1,500 in bonus bets:

Colts vs. Steelers picks, prediction

Over 44.5