
美國紀念斯隆凱特琳癌症中心等機構研究人員分析173名接受造血細胞移植的癌症患者,發現抗生素治療期間攝取越多甜食,腸道菌相多樣性下降越明顯,每增加約100克甜食攝取量,糞便中的腸道菌相多樣性約下降24%,同時腸球菌(尤其是糞腸球菌)增加,高糖分攝取者移植後死亡風險約增加12%。
AI-generated summary
抗生素治療會影響腸道菌相平衡,而飲食因素可能進一步加劇此種失衡。本研究聚焦於接受造血細胞移植的癌症患者,透過分析其住院期間的飲食與糞便樣本,探討甜食攝取量與腸道菌相變化之間的關聯。
2026/10/07 12:06
最新研究發現,接受抗生素治療期間攝取較多甜食,腸道菌相多樣性下降較明顯,並與腸球菌增加有關;圖為情境照。(圖取自freepik)
〔編譯陳成良/綜合報導〕吃抗生素時,如果同時攝取大量甜食,腸道菌叢可能受到更嚴重的干擾。最新研究發現,這種飲食組合會讓原本存在於腸道中的特定細菌趁勢增加,腸道菌相多樣性也隨之下降。
美國有線電視新聞網(CNN)報導,刊登於《自然》(Nature)的研究由美國紀念斯隆凱特琳癌症中心(Memorial Sloan Kettering Cancer Center)等機構研究人員共同進行,分析173名接受造血細胞移植的癌症患者,追蹤他們住院期間攝取的9419份醫院餐點與1009份糞便樣本,結果發現,抗生素治療期間吃的甜食越多,腸道菌相多樣性下降越明顯。
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腸球菌趁菌叢失衡大量擴張
研究人員發現,甜食攝取增加時,腸道中的腸球菌(Enterococcus)也跟著增加。這種細菌平時可以存在於腸道,但受到抗生素影響後,其他細菌數量下降,腸球菌可能失去競爭,進一步大量擴張,其中包括可能造成血流感染的糞腸球菌(Enterococcus faecium)。
研究分析發現,抗生素治療期間,甜食吃得越多,腸道細菌的種類也越少、整體多樣性越低。研究估算,每增加約100克甜食攝取量,糞便中的腸道菌相多樣性約下降24%。
研究也分析患者的臨床結果,發現糖分攝取較高者在移植後的死亡風險約增加12%。不過,研究對象是接受造血細胞移植的癌症患者,且研究並非隨機分配不同飲食,因此這項結果不能直接推論一般人在服用抗生素時吃甜食,也會出現相同程度的感染或死亡風險。
研究作者指出,目前結果顯示,抗生素治療期間攝取大量單純糖,可能進一步加劇腸道菌相失衡;不過是否透過調整飲食就能降低這種影響,仍需要在其他患者族群及不同抗生素使用情境中進一步研究。
AI outlook — possibilities, not facts
未來將在其他患者族群及不同抗生素使用情境中進行進一步研究,以驗證飲食調整是否能降低抗生素治療期間甜食攝取對腸道菌相的影響。
Likely · Within months

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