Houston vs. Colorado prediction, odds, time: Week 11 Friday college football picks from proven model
SportsLine Projection Model projects Over 51.5 points in Friday night matchup at Folsom Field
Quick Look
- The 14th-ranked Houston Cougars (7-2, 4-2 Big 12) face the Colorado Buffaloes (3-6, 1-5 Big 12) at Folsom Field in Boulder on Friday night at 10:15 p.m.
- Houston is a 7.5-point favorite with the over/under at 51.5.
- The SportsLine Projection Model projects the Over, projecting Houston QB Conner Weigman for over 240 yards and two touchdowns and Colorado QB Isaac Wilson for over 240 yards and one score.
AI-generated summary
Why It Matters
Houston is 7-2 overall and 4-2 in Big 12 play, tied for third in the conference. Colorado is 3-6 overall and 1-5 in Big 12 play, tied for 14th in the league. Houston is 2-2 on the road this season. Colorado is 2-2 at home in 2026. Colorado needs a win to avoid clinching a second-straight losing season.
The 14th-ranked Houston Cougars battle Deion Sanders and the Colorado Buffaloes in a key Big 12 matchup on Friday night as the Cougars look to build their College Football Playoff case. Houston is coming off a 31-24 win over Cincinnati on Saturday, while Colorado dropped a 20-10 decision at Arizona State that same day. The Cougars (7-2, 4-2 Big 12), who are tied for third in the conference, are 2-2 on the road this season. The Buffaloes (3-6, 1-5 Big 12), who are tied for 14th in the league, are 2-2 on their home field in 2026. They need a win to avoid clinching a second-straight losing season.
Kickoff is set for 10:15 p.m. ET at Folsom Field in Boulder, Colo. The Cougars are 7.5-point favorites, with the over/under at 51.5 in the latest Houston vs. Colorado odds. Before making any Houston vs. Colorado picks, check out the Houston vs. Colorado predictions from the SportsLine Projection Model.
After simulating Houston vs. Colorado 10,000 times, SportsLine model is going Over 51.5 points at betting apps and the best college football betting sites. The Over hit in last year's meeting. It has also hit in six of the last 10 Cougars games, and in three of the last four Buffaloes games. Houston is the fifth-best scoring team in the Big 12, averaging 35.4 points per game. Defensively, Colorado is 13th, allowing 28.3 points.
The model projects that Houston quarterback Conner Weigman will throw for more than 240 yards and two touchdowns. He has thrown for 2,280 yards and 22 touchdowns with two interceptions on the season. Colorado quarterback Isaac Wilson, meanwhile, is projected to throw for over 240 yards and one score. He has thrown for 1,412 yards and eight touchdowns with eight interceptions this season.
The computer is calling for 55 combined points as the Over is the value side 58% of the time. See the model's spread and money-line picks at SportsLine.
In addition to going Over on the total, the model also says one side of the spread hits in 60% of simulations. You can only get the pick at SportsLine.
Open Questions
- What is the final score of the Houston vs. Colorado game?
- Which side of the spread does the SportsLine model recommend?
- Will Colorado avoid a second-straight losing season?
