Iowa State vs. BYU prediction, odds, time: Week 6 college football Friday picks from proven model
Quick Look
- The eighth-ranked BYU Cougars (4-0, 2-0 Big 12) host the Iowa State Cyclones (3-2, 1-1 Big 12) in a key conference matchup at LaVell Edwards Stadium on Friday night at 10:15 p.m.
- BYU is favored by 11.5 points with an over/under of 46.5, while SportsLine's model projects over 45.5 points and recommends taking the over based on 10,000 simulations.
AI-generated summary
Why It Matters
BYU enters the game unbeaten and ranked eighth nationally, having outscored opponents 149-57 this season. Iowa State comes off a win over West Virginia but struggles against ranked teams and on the road.
The eighth-ranked BYU Cougars will look to stay unbeaten when they battle the visiting Iowa State Cyclones in a key Big 12 Conference matchup on Friday night. Iowa State is coming off a 45-42 win over West Virginia on Saturday, while BYU held off TCU 17-10. The Cyclones (3-2, 1-1 Big 12), who are 0-2 against ranked opponents, are 0-1 on the road this season. The Cougars (4-0, 2-0 Big 12), who have outscored their opponents 149-57, are 2-0 on their home field. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55:
Kickoff is set for 10:15 p.m. ET at LaVell Edwards Stadium in Provo, Utah. Iowa State leads the all-time series 5-1, but BYU won last year's meeting in Iowa. The Cougars are 11.5-point favorites, with the over/under at 46.5 in the latest Iowa State vs. BYU odds. The Cougars are at -469 on the money line (risk $469 to win $100). Before making any BYU vs. Iowa State picks, check out the Iowa State vs. BYU predictions from the SportsLine Projection Model.
Iowa State vs. BYU odds
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Top BYU vs. Iowa State predictions
After simulating Iowa State vs. BYU 10,000 times, SportsLine model is going Over 45.5 points at betting apps. The Under has hit in six of the past nine Iowa State games. The Under is 6-4 over the past 10 BYU games, including two of the past three at home.
Senior quarterback Jaylen Raynor helps power the Cyclones' offense. So far this season, he has completed 58% of his passes for 903 yards and six touchdowns with four interceptions. Sophomore quarterback Bear Bachmeier leads the BYU attack. He has completed 64% of his passes for 704 yards and six touchdowns with one pick. He has also rushed 27 times for 130 yards (4.8 average) and four touchdowns.
SportsLine's model is projecting 52 combined points in this one, making the Over the value 63% of the time in an A-rated pick. See the model's spread and money-line picks at SportsLine.
How to make Iowa State vs. BYU picks
In addition to going Over on the total, the model also says one side of the spread hits over 50% of the time. You can only get the pick at SportsLine.
So who wins Iowa State vs. BYU, and which side of the spread hits in over 50% of simulations? Visit SportsLine now to see which side of the BYU vs. Iowa State spread to jump on, all from the advanced model that's on a 40-35 run on top-rated CFB picks, and find out.
Why you should trust SportsLine's model
What to Watch
AI outlook — possibilities, not facts
The game will go over 45.5 total points.
Likely · Within hours
One side of the spread will hit in over 50% of simulations.
Likely · Within hours
Open Questions
- Will BYU maintain its unbeaten streak against a Cyclones team coming off a confidence-boosting win?
- Can Iowa State's offense overcome its struggles against ranked opponents?
- Which team will gain momentum in the Big 12 standings after this matchup?
