Raiders vs. Patriots odds, picks, prediction, spread, line: NFL Week 5 start time, betting preview, best bets

Two AFC playoff hopefuls meet in NFL Week 5 action when the Las Vegas Raiders visit the New England Patriots.

Vegas got off to a shocking 3-0 start to the season and is coming off a loss to Kansas City, though it was a close affair. The Patriots are 2-2 after an upset win over Buffalo, which few saw coming after how poor New England looked in a blowout loss to Jacksonville in Week 3. Kickoff from Foxborough is set for 1 p.m. ET. DraftKings Sportsbook lists the Patriots as 3.5-point favorites, and the Over/Under is set at 45.5.

We'll break down the latest Raiders vs. Patriots odds from DraftKings Sportsbook and deliver our best bets for the contest with help from the SportsLine Projection Model. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception.The model entered Week 5 of the 2026 NFL season on a 55-44 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns.

Raiders vs. Patriots betting odds (via DraftKings)

Raiders vs. Patriots money line: Raiders +160, Patriots -192

Raiders vs. Patriots over/under: 45.5 (Over -105, Under -115)

Raiders vs. Patriots spread: Patriots -3.5

Raiders vs. Patriots betting preview

How about them Raiders? This team went 3-14 a year ago and brought in a brand-new coaching staff to lead the charge. Part of the offseason turnover was drafting Fernando Mendoza No. 1 overall after a Heisman-winning season at Indiana, but the team has kept him on the sidelines as the veteran Kirk Cousins leads the charge. That decision may be a short-term one, but Cousins has been great so far in Vegas' 3-1 start, tossing 11 touchdowns and at least two in every game. The Raiders finally lost to the Chiefs in their first game against a good team this year, but Vegas held its own in the 30-27 loss. It's clear head coach Klint Kubiak has things moving in the right direction. The big question is whether star running back Ashton Jeanty will play as he's questionable with foot and ankle injuries.

As for the Patriots, what a confusing team they are. They lost a Super Bowl rematch to Seattle in Week 1 with Drake Maye tossing three interceptions in the fourth quarter. They won 20-3 over Pittsburgh in Week 2 but Maye was awful in Week 3, a 35-6 loss to Jacksonville. And then New England goes out and hands Buffalo its first loss in Week 4, a 29-26 Pats win where Maye tossed three touchdowns. Maye hardly has looked like the MVP runner-up he was last year, and the Pats desperately need him to lead the charge, especially with A.J. Brown out of action with an ankle injury.

Raiders vs. Patriots picks, prediction

Patriots -3.5