Week 6 college football picks, predictions: Nearly $2,000 in sportsbook promos at DraftKings, BetMGM, FanDuel

College football fans will be treated to a slew of showdowns on Saturday, and the Week 6 college football lines for matchups like Texas vs. Oklahoma, UCLA vs. Oregon, Georgia vs. Alabama and Penn State vs. USC are available to wager at some of the top betting sites like DraftKings, FanDuel and BetMGM. According to the latest Alabama vs. Georgia odds, the Crimson Tide are favored by 1.5 points, after opening at +3. SportsLine's team of experts have revealed college football predictions for that star-studded SEC showdown, as well as matchups like Indiana vs. Nebraska, Texas vs. Oklahoma, UCLA vs. Oregon, and LSU vs. Kentucky.

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Week 6 college football best bets (odds subject to change): Nebraska (+8) vs. Indiana; Texas (-7.5) vs. Oklahoma; UCLA vs. Oregon: Over 58.5 points; LSU (-9.5) vs. Kentucky; Georgia vs. Alabama: Under 52.5 points.

Nebraska (+8) vs. Indiana: "Nebraska boasts a stronger pass-block win rate (57% vs. 48%) and pass-rush win rate (58% vs. 51%) compared to Indiana," SportsLine expert Jeff Hochman said. "The Cornhuskers' +9 sack differential (compared to Indiana's +3) reflects this edge. Nebraska also leads in net yards per play (+1.12 vs. +0.88), while playing a slightly easier schedule."

Texas (-7.5) vs. Oklahoma: "When the Longhorns have won this rivalry of late, in three of the last four years, they have won by daylight," SportsLine expert Eric Cohen said. "Texas has beaten Oklahoma by 49, 31, and 17 points in those three games and considering the Sooners' offense is a total disaster in 2026, I see a similar outcome occurring on Saturday."

UCLA vs. Oregon: Over 58.5 points: "Dating back to last season, Oregon has scored 42, 42, 51, 34, and 84 points in its last five home games," SportsLine expert Eric Cohen pointed out. "The Ducks are averaging 47.5 points per game this season, while the Bruins are at 44.8 PPG."

LSU (-9.5) vs. Kentucky: "Will Stein has Kentucky headed in the right direction, although the Wildcats are still a notch below the SEC elite," SportsLine expert Thomas Casale said. "My concern in this matchup is Kentucky's rush defense. The Wildcats allowed 232 rushing yards to South Carolina, 187 to Texas A&M, and 155 to Alabama."

Georgia vs. Alabama: Under 52.5 points: "This number has sunk four points since a dire weather forecast was circulated," SportsLine expert Mike Tierney pointed out. "It could travel farther south. The teams are gearing up for hurricane-like conditions, including heavy rain and winds in the mid-20s."