Week 8 NFL odds, picks, predictions: Computer model backs Steelers and Rams

There's a one-week reprieve of international games on the Week 8 NFL schedule as all of your NFL bets will be on domestic matchups. Among them are several contests we could potentially see again come the postseason like Ravens vs. Bills (-3), Vikings vs. Lions (-3.5), Chiefs vs. Broncos (+1.5) and Bears vs. Seahawks (-3). Meanwhile, one of the Week 8 NFL spreads stands out as the Patriots are giving 7 points to Miami. If this NFL line holds, then that would make the Pats the third-biggest road favorite of the season as the Dolphins are one of two home dogs to back with NFL picks.

Other games with large lines per the Week 8 NFL odds include Bengals vs. Titans (+11.5), Jaguars vs. Colts (+10) and Rams vs. Chargers (+6.5). That all-Los Angeles battle has the Chargers as visitors in their own stadium, as the team seeks both its first win and first cover. The Chargers are on a nine-game losing streak and are the only winless team against the spread, while every team has at least two ATS defeats this season. All of the updated Week 8 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 8 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up more than $5,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 8 of the 2026 NFL season on a 58-51 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns.

Now, it has turned its attention to the latest Week 8 NFL odds and NFL betting lines and locked in betting picks for every NFL matchup.

Top Week 8 NFL predictions

We can tell you one of the model's strongest Week 8 NFL picks for the best betting apps is that the Steelers (-3.5, 39.5) cover at home versus the Browns. "At home" is the key phrase as Pittsburgh's riding one of the greatest active streaks in pro sports in the Steel City against Cleveland. The Steelers have won 22 straight home games versus the Browns, a run which dates back to 2004. This year, Pittsburgh is one of three teams 3-0 ATS at home, while the Browns are 2-2 ATS on the road. Cleveland's No. 28 scoring offense won't be able to keep up with a Steelers team that's put up 30-plus points in back-to-back home games as Pittsburgh covers well over 60% of the time.

Another one of its Week 8 NFL predictions: the Rams (-6.5, 45.5) cover versus the Chargers at 4:05 p.m. ET in well over 50% of sims. The league's last winless team, the Chargers have lost nine straight dating back to last year, with Justin Herbert having twice as many turnovers (12) as touchdowns (6) over this span. Jim Harbaugh's squad is also winless versus the line over these nine, while Sean McVay and co. are 6-2 against the spread in non-conference games since 2025. That's the second-best spread record in the NFL, as the Rams get a touchdown-plus victory, with the Over hitting over 60% of the time.

How to make Week 8 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 8 NFL schedule and just revealed six teams projected to win by double digits, potentially giving you a huge payday on alternate lines.