49ers vs. Seahawks prediction, odds, time: NFL Week 5 picks from proven model

The unbeaten San Francisco 49ers head north to Seattle on Sunday to face the Seattle Seahawks in an NFC West showdown. Brock Purdy has steered the Niners to a 4-0 start, but the defense has been just as noteworthy, ranking seventh in yards allowed. Sam Darnold and the Seahawks (3-1) get the 12th Man and a defense that ranks No. 1 in yards allowed. That Seahawks defense allowed just nine points in a sweep of the 49ers last season, en route to a Super Bowl championship. This will be a challenge for that unit versus Purdy, who has accounted for 12 touchdowns and just one interception. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55:

Kickoff is set for 4:25 p.m. ET from Lumen Field in Seattle. The latest 49ers vs. Seahawks odds have Seattle as a 3-point favorite. The over/under for total points scored is 45.5. Before making any Seahawks vs. 49ers picks or 2026 NFL Week 5 predictions or 2026 NFL Week 5 predictions, be sure to see what the SportsLine projection model has to say.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 5 of the 2026 NFL season on a 55-44 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns.

Now, the model has zoned in on 49ers vs. Seahawks. You can head to SportsLine now to see its picks. Here are several NFL odds and betting lines for Seahawks vs. 49ers:

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Top 49ers vs. Seahawks predictions

After 10,000 simulations of 49ers vs. Seahawks , the model is going Over 45.5 points at betting apps. These defenses rank Top 10, but the offenses have been just as effective. The Seahawks have scored at least 30 points in three straight games, while the Niners have tallied 35 and 36 in two of the last three.

Niners edge rusher Nick Bosa will miss this showdown, offering even more of an edge to the Seattle offense. Jaxon Smith-Njigba remains one of the top targets in the NFL. He already has 481 receiving yards and six TDs in just four games. The Niners' pass offense has offered more balance, with George Kittle, Mike Evans and Deebo Samuel Jr. each with at least 185 receiving yards.

The model projects 47 combined points as the Over hits 51% of the time. See which team to back at SportsLine.

How to make 49ers vs. Seahawks picks

In addition to going Over, the model also says one side hits in well over 50% of simulations. See what it is at SportsLine.