
最新研究顯示,50歲以上美國人中72.1%願意接種預防失智症的假設疫苗,僅7.2%明確反對,20.8%持不確定態度;研究指出,不確定性可能比反對更重要,且接種意願隨年齡、教育、收入及個人經驗而提升。
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目前尚無獲核准的預防失智症疫苗,但多項研究顯示某些現有疫苗(如帶狀疱疹、流感、肺炎鏈球菌、Tdap)與較低失智症風險相關,儘管因果關係尚未確立。
最新研究發現,多數50歲以上美國人對預防失智症的疫苗抱持正面態度,約7成表示願意接種。示意圖。(歐新社)
〔財經頻道/綜合報導〕未來如果真的出現能降低失智症風險的疫苗,你會願意接種嗎?最新研究發現,多數50歲以上美國人對預防失智症的疫苗抱持正面態度,約7成表示願意接種,明確表示不願意的人僅約7%。
美國權威雜誌《新聞週刊》(Newsweek)報導,這項刊登於《JAMA Network Open》的研究,由南加州大學舍弗中心健康政策與經濟學研究中心的專家進行,共有1529名50歲以上美國成年人參與。研究人員詢問受訪者,如果未來有一種價格低廉、需要接種多劑的疫苗,而且對失智症高風險族群可降低50%罹病風險,他們是否願意接種。
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這項調查結果於9月21日發表,顯示72.1%的受訪者表示可能、非常可能或一定會接種這類預防性失智症疫苗;20.8%表示「不確定」或持中立態度,另有7.2%表示可能或一定不會接種。
研究主持人蒙塔諾坎波斯(J. Felipe Montano-Campos)指出,這項結果顯示,人們對失智症疫苗的態度,可能與對其他疫苗的態度不同,因此值得單獨進行研究。而最讓他在意的是,「不確定性可能比反對更重要」,因為表示不確定是否接種失智症疫苗的人,比例高於明確表示不願意接種的人。
結果的性別差異相當明顯,調查顯示,23%的女性對接種失智症疫苗感到猶豫,男性則為18.5%;而表示「一定會」接種的女性為29.1%,男性則達38.5%。此外,在50多歲受訪者中,31.1%表示「一定會」接種;70歲以上族群則提高至35.1%。研究進一步調整人口與社經因素後發現,60至69歲以及70歲以上族群的接種意願,都高於50至59歲族群。
研究也發現,收入較高、教育程度較高,以及自己或親近的人曾罹患失智症者,接種意願也較高。研究人員表示,如果未來真的有有效的預防性失智症疫苗問世,了解不同群體之間的態度差異,將有助於疫苗推廣與相關溝通。
不過研究也提醒,這次調查詢問的是受訪者對「假設中的疫苗」是否願意接種,並非實際面對已上市疫苗時的醫療決策,因此結果未必能完全反映未來實際接種情況。
報導指出,一些現有的疫苗已在多項研究中被發現與較低的失智症發生風險有關,這也進一步引發人們對疫苗是否能夠幫助預防或延緩失智症的興趣與研究。
其中包括帶狀疱疹疫苗。史丹佛大學研究人員分析威爾斯成年人的健康紀錄後發現,接種帶狀疱疹疫苗的人,在接下來7年內罹患失智症的可能性,比沒有接種疫苗的人低20%。另據2025年由義大利多所大學及加拿大大學專家進行的研究,其他成人疫苗,包括預防帶狀疱疹、流感、肺炎鏈球菌以及Tdap的疫苗,也都與較低的失智症風險有關。
然而,由於預防失智症並不是這些疫苗原本的目的,紐約州立大學水牛城分校生物醫學工程學教授洛維爾(Jonathan Lovell)表示:「目前仍不清楚兩者之間是否存在因果關係,以及可能有哪些生物學機制造成這種關聯。」
目前已有大量研究投入失智症專用疫苗,雖然已有數種策略進入臨床試驗階段,但目前仍沒有任何一種獲得核准,而阿茲海默症是最常見的失智症類型,其特徵是類澱粉蛋白β斑塊與Tau蛋白糾結在大腦內累積,這兩者皆是蛋白質。洛維爾表示,目前大多數失智症疫苗開發策略,都是設法「刺激患者自身的免疫系統產生抗體」,來對抗這些蛋白質。
密西根州立大學阿茲海默症聯盟(Alzheimer's Alliance)主任、轉譯神經科學教授摩根(David Morgan)說,如果疫苗能夠在足夠早的時間施打,他認為一種以類澱粉蛋白β為標靶的疫苗可以預防阿茲海默症,但失智症仍可能因其他原因發生。
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AI outlook — possibilities, not facts
若未來五年內開發出有效的預防失智症疫苗,接種率將受年齡、教育與個人經驗顯著影響,60歲以上族群可能成為主要接種對象。
Likely · Within years

Hong Kong's health minister Lo Chung-mau announced a greater than 40 per cent reduction in age-standardised cancer mortality rates over the past thirty years at the World Cancer Congress.

The Ministry of Health and Welfare launched the "Census of Elderly Elders Living Alone" in 2026. From July to August, 80,000 elderly people living alone have actually been interviewed, and it is expected to complete interviews with about 700,000 elderly people by the end of 2027. Visitors will wear identification cards, produce official documents, and be accompanied by grassroots personnel such as the district director. They will not ask for personal information such as bankbooks or account numbers. Minister Shi Chongliang emphasized that the purpose of the census is to understand the needs of the elderly and provide precise services, such as meal delivery, emergency rescue equipment and daily care, and to remind the elderly to guard against fraud. Director of Social Welfare Zhou Daojun pointed out that the census also relies on the assistance of grassroots community partners to understand the actual living conditions and incorporate them into future service evaluations. Grandma Lin, who is over 90 years old and was interviewed, said she felt warmed by the sincerity of the visiting staff. Now she is used to participating in community activities and feels the care of "unrelated relatives".

A phase 3 clinical trial published in JAMA found that the drug Loberamisal, when administered intravenously within 48 hours of a stroke, enabled 70% of patients to regain complete functional independence, compared to 57% with standard care, significantly expanding the treatment window beyond the current six-hour limit.

The Ministry of Health and Welfare pointed out that the number of hospital visits for influenza-like illnesses this time was the highest in the same period in the past 10 years. However, the epidemic has reached its peak last week and is expected to gradually decline. The epidemic period may last until November. Executive Dean Zhuo Rongtai said that sufficient drugs and vaccines have been prepared, and public influenza vaccination will be promoted from October 1, and risk communication will be strengthened in conjunction with the health currency policy, and the Ministry of Education will be asked to supervise the implementation of epidemic prevention measures in schools.

Negotiations on the total amount of health insurance ended yesterday. The medical community and consumer representatives reached a consensus. The total growth rate has reached 5.5% for three consecutive years. Minister of Health and Welfare Shi Chongliang said that he will discuss whether to make the meeting public through live broadcast to enhance transparency. Consumer representatives are worried that the negotiations will become a formality and are unable to compete with the medical community. They call for the Legislative Yuan to live broadcast the entire process to accept external supervision.

When losing weight, calorie overexpenditure is often caused by ignoring invisible fat and incorrect cooking methods. Even if you control the staple food and exercise, it is difficult to lose weight. The article points out that processed health foods, natural high-fat foods and hidden fats in cooking are the main obstacles to weight loss. It is recommended to achieve sustainable weight loss by reading labels, changing cooking habits and smart combinations.