
Concomitant use of non-steroidal anti-inflammatory drugs with anticoagulants or antidepressants risks bleeding
General practitioner Svetlana Burnatskaya warned about the dangers of simultaneous use of non-steroidal anti-inflammatory drugs with anticoagulants, other NSAIDs or antidepressants due to the risk of bleeding and toxicity.
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Taking certain groups of medications together can lead to severe side effects.
The use of non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, together with other such drugs, blood thinners or antidepressants is very dangerous for the body, warned Svetlana Burnatskaya, a general practitioner at Medicina JSC.
"In everyday practice and in everyday life, the following risky combinations are most often encountered. The first is NSAIDs and anticoagulants (for example, aspirin, warfarin, rivaroxaban), because both classes of drugs affect coagulation and the gastrointestinal mucosa. When they are taken together, the risk of gastrointestinal bleeding increases sharply. The second combination is NSAIDs and NSAIDs. The toxicity for the stomach, kidneys and cardiovascular system is summed up system; the likelihood of ulcers and bleeding increases,” Burnatskaya said in an interview with Gazeta.Ru.
She also noted a third dangerous combination of drugs - NSAIDs and antidepressants. The risk of bleeding from the gastrointestinal tract increases due to the effect on platelets and gastric mucosa, the doctor emphasized.
To avoid problems when taking such combinations, Burnatskaya recommended dividing them over time or talking to your doctor to change incompatible drugs.

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