
포스텍 연구팀이 큐리언트와 공동으로 CDK7을 억제하는 물질 '모카시클립'을 항체-약물접합체와 결합하면 암세포의 DNA 복구를 막아 항암 효과를 크게 높일 수 있음을 밝혀냈다고 15일 발표했다.
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암세포는 항암제로 인한 DNA 손상을 스스로 복구하여 치료 효과를 감소시키는 경향이 있다.
포스텍(POSTECH)은 생명과학과·융합대학원 김태경 교수, 통합과정 정혜림 연구팀이 큐리언트 연구팀과 공동으로 신약 후보 물질 '모카시클립'을 항체-약물접합체(ADC)와 같이 쓰면 항암 효과가 크게 높아진다는 사실을 밝혀냈다고 15일 밝혔다.
ADC는 암세포를 찾아가는 항체에 강한 항암제를 실어 보내는 일종의 유도 미사일 항암제다.
항암제는 암세포의 DNA를 망가뜨려 암세포를 죽이지만 암세포가 망가진 DNA를 스스로 복구하면 약효가 줄어든다.
연구팀은 세포가 단백질을 만드는 데 시동을 거는 효소 'CDK7'에 주목하고 이를 막기 위한 물질로 큐리언트가 개발 중인 '모카시클립'을 적용했다.
그 결과 암 성장을 이끄는 단백질 활동이 줄었고 암세포가 DNA 손상을 고치는 데 쓰는 유전자 발현도 함께 떨어졌다.
김태경 교수는 "표적 단백질이 적거나 부작용 때문에 용량을 줄여야 하는 환자, 여러 ADC를 차례로 사용하는 환자에게 새로운 치료 전략이 될 수 있을 것"이라고 말했다.

The Ministry of Science and ICT announced that it had selected three urgent research and development tasks, including AI detection of illegal sites, inspection of forest fire recovery drones, and 3D modeling of fire sites.

A joint research team from POSTECH and Kangwon National University developed a method to control particle growth by sequentially adding air and oxygen during the cathode material firing process. The single-crystal cathode material made in this way maintains 83.04% of its initial capacity after charging and discharging 100 times, and its performance is improved compared to existing air or oxygen-only firing methods.

Daegu Gyeongbuk Institute of Science and Technology (DGIST) announced on the 17th that it has launched the 'Quantum Sensing Strategic Project Group' jointly with KAIST, UNIST, and GIST, and aims to secure ultra-precision quantum sensor source technology for 5 years until 2030 by investing 26 billion won in national funds.

The Korea Institute of Civil Engineering and Building Technology announced that it has established a 'datanet' system that links 17 types of administrative data, including energy consumption, commercial districts, and industry licenses for 7.3 million buildings nationwide. Since April 2023, we have collaborated with 16 organizations to integrate 13 types of data to date, and it was carried out as a project by the Ministry of Land, Infrastructure and Transport and published in an international academic journal.

A study of 1,496 unmarried Korean women aged 20-40 found 75% hold ambivalent views on marriage and children, neither strongly for nor against, while 17.7% hold traditional views and 7.4% post-traditional views, with marriage intentions varying significantly across groups.

In a survey by the Korea Institute for Health and Social Affairs, single women who accepted the traditional family view had a high intention to marry, and the compromise type was the most common at 75.0%. Employment status and household income also influenced the intention to marry, and the report emphasized the need to create a gender-equal family environment and institutional support.