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There had previously been concerns about a possible link between GLP-1 drugs, including semaglutide, and the risk of pancreatic cancer based on early reports and animal experiments.
A popular drug for treating diabetes and weight loss, semaglutide does not increase the risk of developing pancreatic cancer. Scientists did not find such a connection when analyzing medical data from almost 100 thousand people taking the drug. The study results were presented at the annual conference of the European Association for the Study of Diabetes (EASD).
Concerns about semaglutide and other GLP-1 drugs arose following early reports of possible side effects and animal experiments in which changes in pancreatic tissue were observed. Therefore, regulators have demanded further testing of whether long-term use of such drugs may increase the risk of cancer.
Scientists analyzed data from 97,464 patients from Denmark, Sweden and Norway who took semaglutide. They were compared with people who received other diabetes medications. In the first group, 131 cases of pancreatic cancer were identified, in the second - 123.
Taking into account the duration of follow-up, the risk of disease did not differ significantly between groups. The scientists also found no evidence that the likelihood of cancer increased with a higher dose of semaglutide or longer use.
The authors believe that the results do not support existing concerns about a link between semaglutide and pancreatic cancer.

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