
Buffalo listed as 3-point road favorite; Kyler Murray inactive, Carson Wentz to start for Minnesota
AI-generated summary
The Minnesota Vikings (6-1) and Buffalo Bills (6-1) meet on Monday Night Football to cap Week 9. The Vikings suffered their first loss of the season last week, falling 19-15 to the Lions. The Bills won 36-10 over the Ravens. Buffalo is a 3-point road favorite, and the over/under is 44.5.
The Minnesota Vikings (6-1) will host the Buffalo Bills (6-1) for Monday Night Football, and it's a high-stakes matchup to cap Week 9 action. Kickoff is scheduled for 8:15 p.m. ET at U.S. Bank Stadium in Minneapolis, and it's a battle of the NFL's top-scoring offense against its top-scoring defense.
The Vikings suffered their first defeat of the season last week, losing 19-15 against the Lions. Meanwhile, the Bills are coming off a 36-10 win over the Ravens. The latest Vikings vs. Bills odds list Buffalo as the 3-point favorite on the road, and the over/under is 44.5. You can also bet NFL player props during Bills vs. Vikings, with Josh Allen priced at -120 to score an anytime touchdown. Vikings quarterback Kyler Murray (hamstring) is inactive, making way for Carson Wentz to start.
The SportsLine Projection Model has simulated Vikings vs. Bills 10,000 times, and SportsLine's team of NFL experts have analyzed MNF to reveal their Bills vs. Vikings prediction, and you can also read our NFL betting preview for Monday Night Football.
Vikings vs. Bills betting preview
Minnesota Vikings defensive coordinator Brian Flores runs the most aggressive scheme in the NFL, and it's paid major dividends for his team through the first eight weeks of the season. Minnesota ranks No. 1 in scoring defense, No. 2 in total defense and No. 1 in pass defense, while advanced metrics favor the Vikings as well (No. 1 in EPA against the pass and No. 3 in EPA against the run).
However, now they'll be going up against Joe Brady, Josh Allen, and the No. 1-ranked scoring offense of the Buffalo Bills. Allen has led Buffalo to scoring drives on 56.6% of possessions so far this season, and the Bills are also top six in the NFL in third-down conversion rate (44.4%), fourth-down conversion rate (77.8%), and red-zone touchdown rate (70%). The chess match between Brady and Flores will be front and center in this primetime matchup.
Bills vs. Vikings picks, best bets
Bills -3
Khalil Shakir Over 3.5 total receptions (-130)
Bills -3
"The Bills vs. Vikings matchup is similar to last week's Lions vs. Vikings one in that it matches up a great offense (Buffalo is 2nd in total offense, 1st in scoring) vs. a great defense (Minnesota is 2nd in total defense and 1st in scoring) and a bad offense vs. a bad defense. And I expect similar results to the Lions' win," SportsLine NFL expert David Bearman said. "Buffalo's defense is also better than the Lions' one that held the Vikings in check. We don't know what the move to Carson Wentz will do for Minnesota's offense, but not sure it matters. Brian Flores' defense blitzes more than anyone in football. Josh Allen has been very effective against the blitz in 2026, particularly by EPA per dropback (2nd in the NFL)." Bet on Vikings vs. Bills at bet365 with bonus code CBSBET365 and get $200 in bonus bets after betting $10:
Khalil Shakir Over 3.5 receptions
AI outlook — possibilities, not facts
Buffalo Bills will defeat the Minnesota Vikings, similar to Detroit's win over Minnesota last week
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