Having just two teams on byes last Sunday likely didn't affect anyone's Fantasy football lineups too much. The same can't be said for this week. Four teams having off undoubtedly shuffles the Week 6 Fantasy football rankings and creates some anxious Fantasy start-sit decisions. Fortunately, some players who got off to slow starts have come on strongly as of late like Drake Maye, Jordan Love, Bucky Irving and Malik Nabers to create a deeper pool of top options to select from with Week 6 Fantasy football picks.
Injuries have piled up around the league, with Lamar Jackson (ankle) and Jalen Hurts (blood clot) headlining the list of quarterbacks who will be out this week. Caleb Williams (hamstring) did practice this week and is expected to play, though he does have a questionable tag officially. At the skill positions, DJ Moore (shoulder), Pat Freiermuth (calf), Quinshon Judkins (ankle) and Omar Cooper (ankle) are among the players heading into Sunday who are listed as questionable.
Before setting your Week 6 Fantasy football lineups, be sure to check out the Week 6 Fantasy football rankings from the proven computer model at SportsLine.
When it comes to ranking players, SportsLine's model beat human experts in Fantasy football for the past several seasons, especially when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home empty-handed.
The same model has a proven track record providing Fantasy football tips, including being ahead of the curve on players like A.J. Brown, Jonathan Taylor, Derrick Henry, Christian McCaffrey, Alvin Kamara and Jahmyr Gibbs. Anybody who banked on players like those could have made a run at their league title.
Now, the model, which simulates every NFL game 10,000 times, has revealed its Fantasy football rankings for Week 6 of the 2026 NFL season. Head to SportsLine now to see them.
Top Week 6 Fantasy football picks
One surprise in Week 6: The model isn't high on Raiders quarterback Kirk Cousins, despite him ranking sixth in Fantasy points for QBs this year. The veteran overachieved to start the year but is coming off his worst game with just 243 passing yards and 1 touchdown versus New England. Cousins is trending in the wrong direction as after having 3 passing TDs in each of the first three weeks, he then had two scores in Week 4 and then one in Week 5. The Raiders will face Buffalo on Sunday, and Cousins has five total fumbles (two lost) and three picks over his last two games against the Bills. Cousins doesn't even crack the top 15 at his position this week as he's one to fade in Week 6 Fantasy football lineups.
Another curveball: the model is high on Colts receiver Josh Downs, despite him being the WR43 in PPR leagues. Downs is coming off 3 catches for 47 yards on Sunday and has averaged 4.5 receptions for 53 yards over his last four games. However, his Fantasy floor and ceiling will be much higher in Week 6 versus the winless Titans. Downs has scored a touchdown in three of his last four games against Tennessee, and this year has seen the Titans allow eight different wideouts to post at least 60 yards or a touchdown in just five games. Downs ranks as a top-20 Fantasy WR this week. For more start/sit Fantasy football advice, be sure to check out the rest of the Week 6 Fantasy football rankings.
How to set Week 6 Fantasy football rankings
The model is also calling for a surprising quarterback you aren't even thinking about to finish in the top six of its Week 6 Fantasy football rankings, ahead of the likes of Dak Prescott and Jayden Daniels. This pick could be the difference between winning big and going home with nothing. See the model's entire Week 6 Fantasy football rankings for PPR and standard leagues here.
