Ole Miss vs. Vanderbilt odds, picks, predictions, start time: Betting preview for college football Week 6
Analysis of the upcoming SEC matchup between No. 9 Ole Miss and Vanderbilt, including betting lines and team performance data.
Quick Look
- 9 Ole Miss faces Vanderbilt in a Week 6 SEC college football game on Saturday at 3:30 p.m.
- Ole Miss enters as a 9.5-point favorite, with the over/under set at 54.5 points.
AI-generated summary
Why It Matters
Ole Miss is coming off a bye week following a loss to Florida. Vanderbilt enters the matchup after consecutive losses to Auburn and Georgia.
The SEC matchup between No. 9 Ole Miss (3-1) and Vanderbilt (3-2) will be included on the Saturday slate for Week 6 of the college football season scheduled for a 3:30 p.m. ET kickoff. Ole Miss has won five consecutive games against Vanderbilt, which includes a 33-7 victory at home during their last matchup in 2023. The Rebels are currently a 9.5-point favorite, according to the latest Ole Miss vs. Vanderbilt odds on several major betting sites. The over/under for total points scored is 54.5.
We'll look at the latest Ole Miss vs. Vanderbilt odds and spread at FanDuel Sportsbook before breaking down Saturday's SEC matchup. We'll also share our best bets using the SportsLine Projection Model, which simulates every FBS game 10,000 times and provides expert analysis on this week's college football matchups, going 40-35 on all top-rated college football betting sites entering Week 6.
Ole Miss vs. Vanderbilt betting odds
Ole Miss vs. Vanderbilt money line: Ole Miss -375, Vanderbilt +290 Ole Miss vs. Vanderbilt over/under: 54.5 (Over -115, Under -105) Ole Miss vs. Vanderbilt spread: Ole Miss -9.5
Ole Miss vs. Vanderbilt betting preview
Ole Miss is coming off a bye week after being handed its first loss, a 52-28 blowout at Florida, in Week 4. Quarterback Trinidad Chambliss threw for 298 yards, one touchdown and one interception on 25 of 34 passing, while also recording a team-best 44 yards and two touchdowns on seven rushing attempts in the loss.
Vanderbilt is coming off back-to-back losses to Auburn, 21-15, and Georgia, 38-14, ahead of Week 6. The Commodores faced a 21-14 deficit at halftime against Georgia before allowing 17 unanswered points in the second half.
Ole Miss vs. Vanderbilt picks, prediction
Vanderbilt +9.5 vs. Ole Miss
Vanderbilt is 3-2 in its last five games against-the-spread, having covered in each of its last three games, including its first two SEC games of the season. The Commodores have a 2-0 ATS record as the underdog and 1-0 ATS against ranked opponents, but are 1-2 as the home team. Running back Sedrick Alexander leads Vanderbilt with 200 yards and four touchdowns on 45 rushing attempts, which includes 35 yards and one touchdown on eight attempts last Saturday.
Ole Miss is 1-3 against-the-spread, with its one cover coming in its Week 3 win against LSU, having closed as a 3-point underdog at home. The Rebels have a 0-1 ATS record as an away team and a 0-2 ATS record as the favorite in 2026. Chambliss is leading the SEC with 305.5 passing yards per game, having thrown for 1,222 yards, eight touchdowns and three interceptions on 102 of 144 passing, while also recording 108 yards and four touchdowns on 28 rushing attempts.
