Omega-3 and Omega-6 Fatty Acids Revealed to Weaken Cancer Immunotherapy

An unknown and dangerous side of unsaturated fatty acids, which are widely used as food supplements in the world of medicine, oncology and immunotherapy, has been revealed. Preclinical studies conducted by experts in the Vascular Biology and Therapeutics Program at Yale University School of Medicine and Weill Cornell Medical College have yielded game-changing results.

According to the study published in the journal Science Signaling, Omega-3 and Omega-6 polyunsaturated fatty acids (PUFA), which are recommended for heart and brain health, blunt the lethal power of immune cells fighting cancer.

NATURAL KILLER CELLS ARE DISARMED THROUGH THE "LRP5" PROTEIN

from Yale University. Yi Luan and his team examined the cellular behavior of "natural killer cells" (NK), which are the first responders of the immune system and directly destroy infected tissues and cancerous cells, in response to Omega oils.

In laboratory tests, it was determined that Omega fatty acids bind to a carrier protein called "LRP5" at the cellular level and enter natural killer cells. It has been documented that fats entering the cell completely suppress the antitumor function of the immune system and its capacity to destroy cancerous tissue.

LINOLEIC ACID IN SEED OILS ENLARGES BREAST CANCER

In parallel research conducted by Weill Cornell Medical College, it was determined that linoleic acid (Omega-6), found in seed oils such as soy and safflower and animal foods, sharply increased tumor growth in cases of "triple negative breast cancer", one of the most difficult types of cancer to treat.

It was observed that linoleic acid directly activated the growth pathways of cancerous tissues by binding to the FABP5 protein in tumor cells.

PERSONALIZED NUTRITION PERIOD FOR PATIENTS RECEIVING IMMUNOTHERAPY

Researchers reported that if the LRP5 protein is blocked in the laboratory environment or unsaturated fatty acids are removed from the subjects' diet, tumor growth slows down and the success of immunotherapy drugs is multiplied.

Dr. Yi Luan and Dr. John Blenis emphasized that the data obtained show that general food supplement recommendations for patients receiving cancer treatment are inadequate. Experts declared that personalized nutrition (precision medicine) prescriptions should be prepared according to the type of cancer and the patient's cellular profile.