Rams vs. Bills odds, prediction, betting preview, start time: Monday Night Football picks, best bets
Quick Look
- The Los Angeles Rams host the Buffalo Bills in Monday Night Football to close Week 5 of the 2026 NFL season, with Matthew Stafford and Josh Allen — the last two NFL MVPs — set to duel.
- The Rams are 3.5-point favorites at SoFi Stadium, despite a 2-2 start, while the Bills enter at 3-1 following a loss to the Patriots.
- Key injuries include Myles Garrett out for LA and Ed Oliver ruled out for Buffalo, with D.J.
AI-generated summary
Why It Matters
The Rams began the 2026 season as title favorites but have started 2-2, including a loss in Australia to the 49ers and a blown halftime lead against the Broncos. The Bills are 3-1 after their first loss of the season to the Patriots and possess the NFL's top scoring offense through four weeks.
The Los Angeles Rams will host the Buffalo Bills for Monday Night Football to conclude Week 5 of the 2026 NFL season. Matthew Stafford and Josh Allen are the last two NFL MVPs, and the two quarterbacks will go head-to-head in a potential Super Bowl preview. The Rams (2-2) began the year as title favorites but were up and down in their first month of the season, while the Bills (3-1) are coming off their first loss of the season to the Patriots. The latest Rams vs. Bills odds list Los Angeles as the 3.5-point favorite at home, and the over/under is 54.5 points. Stafford's over/under for total passing yards is 282.5, while Allen to record 2+ passing touchdowns is priced at -104. Claim the Kalshi promo code CBSSPORTS55 here now and get a $55 bonus after $25 in trades:
Kickoff for Bills vs. Rams is set for 8:15 p.m. ET at SoFi Stadium in Inglewood, Calif. SportsLine's team of NFL experts have analyzed MNF and revealed their Rams vs. Bills prediction, and you can also read our NFL betting preview for Monday Night Football. Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after $10 in trades:
Rams vs. Bills betting preview
The Rams remain Super Bowl favorites despite a 2-2 start that included a blowout loss in Australia to the 49ers and a loss to the Broncos where they blew a 16-point halftime lead. DraftKings prices Los Angeles at +650 to win the title entering Week 5, just ahead of their opponent this week with Buffalo checking in at +750. Myles Garrett (knee) remains out following surgery but Aaron Donald (back) will return to action in Week 5.
Meanwhile, the Bills have the NFL's top scoring offense through four weeks and Josh Allen is once again playing at an MVP level. However, wide receiver D.J. Moore (shoulder) is listed as questionable for Monday's matchup and defensive tackle Ed Oliver (knee) has already been ruled out. Expect Buffalo to lean heavily on Allen and star running back James Cook. Claim $200 in bonus bets after your first $5 wager at DraftKings here:
Rams vs. Bills picks, best bets
Rams -3.5 (-104)
Kyren Williams Over 89.5 rushing + receiving yards (-115)
Rams -3.5 (-104)
"The Rams got peerless WR Puka Nacua back last weekend. They expect to have future Famer Aaron Donald at DT back for this one. His return is welcome against a gifted offense but one that has committed seven turnovers the past two games amid concerns about QB Josh Allen's ailing knee," SportsLine NFL expert Mike Tierney said. "L.A.'s defense has performed far better than Buffalo's. The Rams' remarkable comeback to win in Philly last Sunday sets them up for a fifth consecutive cover at home." Bet on Bills vs. Rams at bet365 with bonus code CBSBET365 and get $200 in bonus bets after betting $10:
Kyren Williams Over 89.5 rushing + receiving yards (-115)
What to Watch
AI outlook — possibilities, not facts
The Rams will cover the -3.5 point spread at home.
Likely · Within hours
Kyren Williams will exceed 89.5 rushing + receiving yards.
Likely · Within hours
Open Questions
- Will Aaron Donald's return significantly impact the Rams' defensive performance?
- Can Josh Allen overcome concerns about his ailing knee to maintain MVP-level play?
- How will the absence of Myles Garrett affect the Rams' pass rush?
