
AI-generated summary
SportsLine's computer simulation model simulates every NFL game 10,000 times to generate betting picks. It has returned over $7,000 for $100 players since inception and enters the 2026 season on a 53-37 run on top-rated picks dating back to 2024.
Many bettors are familiar with creating an NFL parlay, but far fewer are well versed with making an NFL longshot parlay. These are high-risk, high-reward predictions often involving multiple legs or plus-money NFL bets, if not both. A Week 1 NFL parlay could target alternate lines, any time touchdown scorers, winning margins and more. Which combination of Week 1 NFL picks and player props should you consider for a huge payday? New to sports trading? Visit our Kalshi promo code review and get a $25 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS:
The Texans face the Bills at 1 p.m. ET on Sunday, and Houston (+1.5) has scored exactly 23 points in back-to-back games versus Buffalo. Hitting on the NFL best bet of Houston scoring exactly 23 points again on Sunday carries a +1700 return, as that could be a standalone pick or one parlay leg. Before making any Week 1 NFL picks or parlays, you need to see the Week 1 NFL longshot parlay from SportsLine's proven computer simulation that pays out $1 million on a $10 bet.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model enters the 2026 NFL season on a 53-37 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns.
Now that the simulation model has had a chance to digest the Week 1 NFL odds, it's locked in its betting picks to form a longshot NFL parlay that could pay out $1 million for a $10 bettor. You can only see the picks and full parlay by heading to SportsLine.
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Top Week 1 NFL parlay picks
For Week 1, one of the picks featured in the six-leg parlay at the best betting apps is taking Over 56.5 points on the alternate total (+226) in Cowboys vs. Giants. Dallas is on its fourth defensive coordinator in four years, as it ranked dead last in points allowed in 2025 after ranking second worst in 2024. Meanwhile, the Giants have a new DC as well, and he presided over units in Tennessee that ranked 28th and 30th in scoring defense each of the last two years. Additionally, recent matchup history indicates we'll see a shootout in this 'Sunday Night Football' contest.
The teams saw 77 total points on the scoreboard in their first matchup last year, while the second seemed headed that way until Dallas pulled its starters in a meaningless Week 18 game. Even with that, the last six meetings between these two in New York have averaged 62.2 points, with two of them exceeding 70 combined points. The model actually projects 59 total points on SNF, giving you some wiggle room. See the rest of the picks in the Week 1 NFL parlay here.
How to make NFL parlay picks for a payout of $1 million
The parlay also includes five additional picks from Week 1 from SportsLine's computer model, including multiple touchdown props that return +700 or more. You can only see the picks and the full parlay at SportsLine.
AI outlook — possibilities, not facts
The Week 1 NFL longshot parlay will pay out $1 million on a $10 bet if all legs win.
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The Chicago Bears have agreed to a three-year, $33.75 million contract extension with running back D'Andre Swift, including $27.5 million guaranteed, securing him through the 2026 season. The deal replaces his original 2024 contract that was set to expire after this year.

Arizona added running back Ismail Mahdi, linebacker Max Harris, and punter Sullivan Moon to its roster after a Pima County judge granted them a temporary restraining order against the NCAA, clearing them to play in Saturday's Big 12 game against No. 15 BYU. Mahdi and Harris are expected to travel and contribute, with Mahdi leading the team in rushing last season and Harris registering 3.5 tackles for loss. The Wildcats aim to end a five-game losing streak to BYU and build momentum for a favorable stretch of games.

Oklahoma head coach Brent Venables rejects claims that Michigan is overrated despite their narrow win and AP Top 25 drop, praising their defense and quarterback John Mateer's performance, while questioning Michigan's Bryce Underwood ahead of their Week 2 non-conference game in Ann Arbor.

NFL Week 1 game predictions are provided for all 16 matchups, featuring point spreads, broadcast details, and reasoning based on quarterback situations, injuries, coaching changes, and team dynamics, with the Steelers, Ravens, Bills, Bears, Jaguars, Lions, Jets, Bengals, Chargers, Packers, Raiders, Eagles, Cowboys, and Chiefs selected as winners.

Mississippi State and Minnesota meet for the first time in a Big Ten vs. SEC nonconference clash, with Mississippi State's sophomore quarterback Kamario Taylor seeking a breakout performance and Minnesota aiming to revive its struggling rushing attack against an SEC defense, as both teams look to shape early conference perceptions.

No. 4 Texas hosts No. 1 Ohio State in a Week 2 college football rematch of last season's opener, with Texas favored due to returning starters and new offensive additions like Cam Coleman, while Ohio State relies on a reloaded defense and experienced quarterback Julian Sayin despite offseason losses.