
SportsLine expert Eric Cohen provides score predictions and betting insights for Week 5 divisional matchups.
AI-generated summary
Week 5 of the NFL season features several divisional matchups. Expert Eric Cohen has a recorded 188-96-1 straight-up record from the 2025-26 season.
There are five divisional games on Sunday, and common matchups could certainly help making Week 5 NFL score predictions. Seahawks vs. 49ers (+3, 46.5) is one of those, with Seattle having a discernible scoring trend. It scored 13 points in both regular season matchups last season, as the Seahawks have scored exactly 13 points in four of their last seven meetings with San Fran in the regular season. If you expect that NFL trend to continue, then you're halfway to nailing a Week 5 NFL exact score bet.
Other divisional contests to place Week 5 NFL bets on include Packers vs. Bears (-1.5), Texans vs. Titans (+7), Giants vs. Commanders (-3.5) and Broncos vs. Chargers (+3.5). Jayden Daniels will return for Washington after leaving Week 2 with an elbow injury. Meanwhile, Green Bay is a home underdog to Chicago for the first time in 20 years. Before making any Week 5 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen.
A SportsLine expert and host, Cohen is evaluating the entire Week 5 NFL slate and delivers score predictions and logic for each matchup. He finished the 2025-26 season with a 188-96-1 straight-up record (66%) with his picks at NFL betting sites and is 38-26 (59%) on his 2026 NFL picks. Anyone who followed Cohen's NFL predictions on betting sites could have seen strong returns.
Now, Cohen has analyzed the latest NFL odds and made his Week 5 NFL picks. You can only see Cohen's Week 5 NFL exact score predictions at SportsLine.
Top Week 5 NFL picks
After diving into all 15 games from the NFL Week 5 schedule, Cohen recommends backing the Texans (-6.5, 38.5) to defeat the Titans at the best betting apps. While the Titans defense has, surprisingly, performed better than Houston's defense, the Titans offense has outperformed no one this season. It ranks dead last in total yards and is second worst in points scored. Meanwhile, Houston's scored 30-plus in its two games with Nico Collins healthy, and the Texans' run defense is still stout in ranking fourth in yards allowed and yards per carry given up. To help with the NFL exact score prediction, the Titans have scored in between 13 and 16 points in five straight home games versus Houston, and Cohen points out the overall low-scoring nature of this rivalry.
"Shockingly, this is a matchup of 0-4 teams whose seasons effectively end with a fifth straight loss. The downfall of Houston defensively is shocking. But fortunately, they face a really bad Tennessee offense on Sunday so maybe this is their get right spot. Also, eight of the last ten meetings between these two franchises have seen 37 or less points. Expect a low-scoring, ugly game with the Texans starting their long road back to .500 with a two-score win." Texans 22, Titans 13
How to make Week 5 NFL score predictions
In addition, Cohen has identified eight games where the team with the worse record prevails. Nailing these results is key to making profitable Week 5 NFL picks. You can only see them at SportsLine.
AI outlook — possibilities, not facts
Texans to defeat Titans with a score of 22-13.
Speculative · Within days

The New England Patriots host the Las Vegas Raiders in a Week 5 NFL matchup. The Patriots enter at 2-2 following an upset win over Buffalo, while the 3-1 Raiders look to bounce back from a narrow loss to the Kansas City Chiefs.

The Cincinnati Bengals face the Miami Dolphins in Week 5 of the NFL season. With the Bengals at 2-2 and the Dolphins at 0-4, prediction markets favor Cincinnati, though injury concerns for Ja'Marr Chase and Tee Higgins remain key factors for the game's outcome.

SportsLine expert Mike McClure provides DFS lineup advice for the Week 5 NFL main slate, highlighting high-value targets like Jahmyr Gibbs and Romeo Doubs based on his proprietary prediction model.

The Chicago Bears (3-1) face the Green Bay Packers (2-2) at Lambeau Field this Sunday. Tyson Bagent will start for Chicago as Caleb Williams recovers from a hamstring injury. SportsLine's model projects a high-scoring game, favoring the Over at 46.5 points.

The 2026 MLB postseason reaches the League Championship Series with the Rays, Guardians, Brewers, and Dodgers remaining. Each team faces a pivotal question regarding player health, performance trends, or tactical matchups that will shape the World Series race.

SportsLine experts provide betting analysis and picks for Week 5 NFL divisional games, including Bears vs. Packers, Titans vs. Texans, and Seahawks vs. 49ers, while highlighting current betting odds and promotional offers.